Evidence map›Paper›PMID 34679417›Full record

ArticleBrain sciences2021

Reduced Axon Calibre in the Associative Striatum of the

Eliana Lousada, Mathieu Boudreau, Julien Cohen-Adad, Brahim Nait Oumesmar, Eric Burguière, Christiane Schreiweis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Wrap it up: myelination of transplanted neurons for repair.Frontiers in cellular neuroscience · 2025
    Review
  3. Article
  4. The Sapap3Translational psychiatry · 2023
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Eliana LousadaTeam 'Neurophysiology of Repetitive Behaviours' (NERB), Institut du Cerveau, Inserm U1127, Centre National de la Recherche Scientifique (CNRS) U7225, Sorbonne Universités, Hôpital de la Pitié-Salpêtrière, 75013 Paris, France.
Mathieu BoudreauMontreal Heart Institute, Montréal, QC H1T 1C8, Canada.
Julien Cohen-AdadNeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, QC H3T 1J4, Canada.ORCID 0000-0003-3662-9532
Brahim Nait OumesmarTeam 'Myelin Plasticity and Regeneration', Institut du Cerveau, Inserm U1127, Centre National de la Recherche Scientifique (CNRS) U7225, Sorbonne Universités, Hôpital de la Pitié-Salpêtrière, 75013 Paris, France.ORCID 0000-0002-1646-6281
Eric BurguièreTeam 'Neurophysiology of Repetitive Behaviours' (NERB), Institut du Cerveau, Inserm U1127, Centre National de la Recherche Scientifique (CNRS) U7225, Sorbonne Universités, Hôpital de la Pitié-Salpêtrière, 75013 Paris, France.
Christiane SchreiweisTeam 'Neurophysiology of Repetitive Behaviours' (NERB), Institut du Cerveau, Inserm U1127, Centre National de la Recherche Scientifique (CNRS) U7225, Sorbonne Universités, Hôpital de la Pitié-Salpêtrière, 75013 Paris, France.
Centre National de la Recherche Scientifique · FRInstitut Universitaire de Gériatrie de Montréal · CAMontreal Heart Institute · CA

Funding

Agence National de la Recherche ANR-16-INSERM-SINREP, ANR-19-ICM-DOPALOOPSCanada First Research Excellence Fund IVADO and TransMedTechCanada Foundation for Innovation 32454, 34824Canada Research Chair in Quantitative Magnetic Resonance Imaging 950-230815Canadian Institutes of Health Research CIHR FDN-143263Fonds de Recherche du Québec - Santé 28826ICM Big Brain Theory (BBT) BBT-ACTIMYELInvestissements d'avenir ANR-10-IAIHU-06 and ANR-11-INBS-0011-NeurATRISL'Oréal-UNESCO L'Oréal-UNESCO Fellowship 2016Natural Sciences and Engineering Research Council of Canada RGPIN-2019-07244Quebec BioImaging Network 5886, 35450
6 · The paper itself

Abstract

Pathological repetitive behaviours are a common feature of various neuropsychiatric disorders, including compulsions in obsessive-compulsive disorder or tics in Gilles de la Tourette syndrome. Clinical research suggests that compulsive-like symptoms are related to associative cortico-striatal dysfunctions, and tic-like symptoms to sensorimotor cortico-striatal dysfunctions. The

Indexed as

associative and sensorimotor striatumaxon calibreAxonDeepSegcompulsive-like and tic-like behavioursmyelinationobsessive–compulsive disorderrepetitive behavioursSapap3 knockout mouse modelstructural cortico-striatal connectivityTourette syndrome

Identifiers

PMID34679417
PMCPMC8570333
OpenAlexW3205007598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.