Evidence map›Paper›PMID 34679413›Full record

ArticleBrain sciences2021

The Department of Veterans Affairs Gulf War Veterans' Illnesses Biorepository: Supporting Research on Gulf War Veterans' Illnesses.

Christopher B Brady, Ian Robey, Thor D Stein, Bertrand R Huber, Jessica Riley, Nazifa Abdul Rauf, Keith R Spencer, Gabriel Walt, Latease Adams, James G Averill and 4 more

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Christopher B BradyResearch and Development Service, VA Boston Healthcare System, Boston, MA 02130, USA.ORCID 0000-0002-6095-6480
Ian RobeySouthern Arizona VA Healthcare System, Tucson, AZ 85723, USA.
Thor D SteinPathology Service, VA Boston Healthcare System, Boston, MA 02130, USA.
Bertrand R HuberDepartment of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
Jessica RileyResearch and Development Service, VA Boston Healthcare System, Boston, MA 02130, USA.
Nazifa Abdul RaufResearch and Development Service, VA Boston Healthcare System, Boston, MA 02130, USA.
Keith R SpencerResearch and Development Service, VA Boston Healthcare System, Boston, MA 02130, USA.
Gabriel WaltResearch and Development Service, VA Boston Healthcare System, Boston, MA 02130, USA.
Latease AdamsResearch and Development Service, VA Boston Healthcare System, Boston, MA 02130, USA.
James G AverillSouthern Arizona VA Healthcare System, Tucson, AZ 85723, USA.
Sean WalkerSouthern Arizona VA Healthcare System, Tucson, AZ 85723, USA.
Ann C McKeePathology Service, VA Boston Healthcare System, Boston, MA 02130, USA.
Stephen P ThomsonSouthern Arizona VA Healthcare System, Tucson, AZ 85723, USA.
Neil W KowallDepartment of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
Boston University · USVA Boston Healthcare System · USSouthern Arizona VA Health Care System · USUniversity of Arizona · US

Funding

Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
Age-Associated Lipidomic Changes in Alzheimer's DiseaseRF1AG057768 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BLUSZTAJN, JAN KRZYSZTOF, STEIN, THOR · 2019 to 2021
$4.5M
Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive declineRF1AG054156 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, RYU, HOON · 2016 to 2018
$3.4M
Age-Associated Lipidomic Changes in Alzheimer's DiseaseR56AG057768 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BLUSZTAJN, JAN KRZYSZTOF, STEIN, THOR · 2017 to 2017
$820k
VA Biorepository Brain BankI01BX002466 · VA · VA BOSTON HEALTH CARE SYSTEM · PI Ann C. McKee, Haining Zhu · 2014 to 2026
–
BLRD VA I01 BX003063NIA NIH HHS P30AG13846NIA NIH HHS R56 AG057768NIA NIH HHS R56AG057768NIA NIH HHS RF1AG054156NIA NIH HHS RF1 AG057768
6 · The paper itself

Abstract

aimsTo introduce a resource supporting research on Gulf War illness (GWI) and related disorders, the Gulf War Veterans' Illnesses Biorepository (GWVIB).

methodsGulf War era veterans (GWVs) are recruited nationally and enrolled via telephone and email/postal mail. Enrolled veterans receive annual telephone and mail follow-up to collect health data until their passing. A postmortem neuropathological examination is performed, and fixed and frozen brain and spinal cord samples are banked to support research. Investigators studying GWI and related disorders may request tissue and data from the GWVIB.

resultsAs of September 2021, 127 GWVs from 39 states were enrolled; 60 met the criteria for GWI, and 14 met the criteria for chronic multisymptom illness (CMI). Enrollees have been followed up to six years. Postmortem tissue recoveries were performed on 14 GWVs. The most commonly found neuropathologies included amyotrophic lateral sclerosis, chronic traumatic encephalopathy, and Lewy body disease. Tissue was of good quality with an average RNA integrity number of 5.8 (SD = 1.0) and ≥4.8 in all of the cases. DISCUSSION: The availability of health data and high-quality CNS tissue from this well-characterized GWV cohort will support research on GWI and related disorders affecting GWVs. Enrollment is ongoing.

Indexed as

brain bankingchronic multisymptom illnessgulf wargulf war illnessneuropathologytissue bankingveterans

Identifiers

PMID34679413
PMCPMC8533803
OpenAlexW3206597581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.