Evidence map›Paper›PMID 34679363›Full record

ArticleBrain sciences2021

Screening of Parkinson's Disease Using Geometric Features Extracted from Spiral Drawings.

Jay Chandra, Siva Muthupalaniappan, Zisheng Shang, Richard Deng, Raymond Lin, Irina Tolkova, Dignity Butts, Daniel Sul, Sammer Marzouk, Soham Bose and 4 more

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Jay ChandraHarvard College, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-1674-0180
Siva MuthupalaniappanHarvard College, Harvard University, Cambridge, MA 02138, USA.
Zisheng ShangGlobal Alliance for Medical Innovation, Cambridge, MA 02138, USA.ORCID 0000-0001-6322-3381
Richard DengGlobal Alliance for Medical Innovation, Cambridge, MA 02138, USA.
Raymond LinHarvard College, Harvard University, Cambridge, MA 02138, USA.
Irina TolkovaSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-2989-7283
Dignity ButtsHarvard College, Harvard University, Cambridge, MA 02138, USA.
Daniel SulGlobal Alliance for Medical Innovation, Cambridge, MA 02138, USA.
Sammer MarzoukHarvard College, Harvard University, Cambridge, MA 02138, USA.
Soham BoseHarvard College, Harvard University, Cambridge, MA 02138, USA.
Alexander ChenHarvard College, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0001-6484-7217
Anushka BhaskarHarvard College, Harvard University, Cambridge, MA 02138, USA.
Sreekar MantenaHarvard College, Harvard University, Cambridge, MA 02138, USA.
Daniel Z PressCognitive Neurology Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Harvard University Press · USDuke University · USBeth Israel Deaconess Medical Center · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional means of Parkinson's Disease (PD) screening rely on qualitative tests typically administered by trained neurologists. Tablet technologies that enable data collection during handwriting and drawing tasks may provide low-cost, portable, and instantaneous quantitative methods for high-throughput PD screening. However, past efforts to use data from tablet-based drawing processes to distinguish between PD and control populations have demonstrated only moderate classification ability. Focusing on digitized drawings of Archimedean spirals, the present study utilized data from the open-access ParkinsonHW dataset to improve existing PD drawing diagnostic pipelines. Random forest classifiers were constructed using previously documented features and highly-predictive, newly-proposed features that leverage the many unique mathematical characteristics of the Archimedean spiral. This approach yielded an AUC of 0.999 on the particular dataset we tested on, and more importantly identified interpretable features with good promise for generalization across diverse patient cohorts. It demonstrated the potency of mathematical relationships inherent to the drawing shape and the usefulness of sparse feature sets and simple models, which further enhance interpretability, in the face of limited sample size. The results of this study also inform suggestions for future drawing task design and data analytics (feature extraction, shape selection, task diversity, drawing templates, and data sharing).

Indexed as

Archimedean Spiralbiomarkerdigitized drawingdisease screeningfeature extractionmachine learningParkinson’s Disease

Identifiers

PMID34679363
PMCPMC8533717
OpenAlexW3201737395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.