Evidence map›Paper›PMID 34679360›Full record

ReviewBrain sciences2021

Neonatal Seizures: An Overview of Genetic Causes and Treatment Options.

Giulia Spoto, Maria Concetta Saia, Greta Amore, Eloisa Gitto, Giuseppe Loddo, Greta Mainieri, Antonio Gennaro Nicotera, Gabriella Di Rosa

Open access · goldAbstract readReview
In one paragraph

Review in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Status epilepticus in the neonate.BMJ paediatrics open · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Observational
  10. Article
  11. Review
  12. Article
  13. Genetic Background of Epilepsy and Antiepileptic Treatments.International journal of molecular sciences · 2023
    Review
  14. International journal of molecular sciences · 2022
    Article
  15. Review
  16. Clinical whole exome sequencing revealedSaudi journal of biological sciences · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Giulia SpotoUnit of Child Neurology and Psychiatry, Department of Human Pathology of the Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Maria Concetta SaiaUnit of Child Neurology and Psychiatry, Department of Human Pathology of the Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Greta AmoreUnit of Child Neurology and Psychiatry, Department of Human Pathology of the Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.ORCID 0000-0001-8407-3052
Eloisa GittoUnit of Neonatal Intensive Care, Department of Human Pathology of the Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Giuseppe LoddoAzienda USL di Bologna, 40124 Bologna, Italy.ORCID 0000-0001-8748-5984
Greta MainieriDepartment of Biomedical and NeuroMotor Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-6159-854X
Antonio Gennaro NicoteraUnit of Child Neurology and Psychiatry, Department of Human Pathology of the Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Gabriella Di RosaUnit of Child Neurology and Psychiatry, Department of Human Pathology of the Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
University of Messina · ITAzienda USL di Bologna · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seizures are the most frequent neurological clinical symptoms of the central nervous system (CNS) during the neonatal period. Neonatal seizures may be ascribed to an acute event or symptomatic conditions determined by genetic, metabolic or structural causes, outlining the so-called 'Neonatal Epilepsies'. To date, three main groups of neonatal epilepsies are recognised during the neonatal period: benign familial neonatal epilepsy (BFNE), early myoclonic encephalopathy (EME) and 'Ohtahara syndrome' (OS). Recent advances showed the role of several genes in the pathogenesis of these conditions, such as

Indexed as

benign familial neonatal epilepsyearly-infantile epileptic encephalopathyearly myoclonic encephalopathyepilepsygenotype-phenotype correlationneonatal epilepsyneonatal seizures

Identifiers

PMID34679360
PMCPMC8534058
OpenAlexW3201834347

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.