Evidence map›Paper›PMID 34679259›Full record

ArticleJournal of diabetes investigation2022

Association of glycated hemoglobin at an early stage of pregnancy with the risk of gestational diabetes mellitus among non-diabetic women in Japan: The Japan Environment and Children's Study.

Tetsuo Sekine, Kyoichiro Tsuchiya, Hiroyuki Uchinuma, Sayaka Horiuchi, Megumi Kushima, Sanae Otawa, Hiroshi Yokomichi, Kunio Miyake, Yuka Akiyama, Tadao Ooka and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Tetsuo SekineThird Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
Kyoichiro TsuchiyaThird Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.ORCID https://orcid.org/0000-0001-9829-1018
Hiroyuki UchinumaThird Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
Sayaka HoriuchiCenter for Birth Cohort Studies, University of Yamanashi, Chuo City, Yamanashi, Japan.
Megumi KushimaCenter for Birth Cohort Studies, University of Yamanashi, Chuo City, Yamanashi, Japan.
Sanae OtawaCenter for Birth Cohort Studies, University of Yamanashi, Chuo City, Yamanashi, Japan.
Hiroshi YokomichiDepartment of Health Sciences, School of Medicine, University of Yamanashi, Chuo City, Yamanashi, Japan.ORCID https://orcid.org/0000-0001-7369-155X
Kunio MiyakeDepartment of Health Sciences, School of Medicine, University of Yamanashi, Chuo City, Yamanashi, Japan.
Yuka AkiyamaDepartment of Health Sciences, School of Medicine, University of Yamanashi, Chuo City, Yamanashi, Japan.
Tadao OokaDepartment of Health Sciences, School of Medicine, University of Yamanashi, Chuo City, Yamanashi, Japan.
Reiji KojimaDepartment of Health Sciences, School of Medicine, University of Yamanashi, Chuo City, Yamanashi, Japan.
Ryoji ShinoharaCenter for Birth Cohort Studies, University of Yamanashi, Chuo City, Yamanashi, Japan.
Shuji HirataDepartment of Obstetrics and Gynecology, University of Yamanashi, Yamanashi, Japan.
Zentaro YamagataCenter for Birth Cohort Studies, University of Yamanashi, Chuo City, Yamanashi, Japan.
Japan Environment and Children’s Study Group
University of Yamanashi · JPUniversity of Yamanashi Hospital · JP

Funding

Ministry of the Environment, Japan
6 · The paper itself

Abstract

AIMS/

introductionGestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and is associated with adverse pregnancy outcomes. This study aimed to explore the associations between glycated hemoglobin (HbA1c) levels at the early stage of pregnancy and the GDM risk among non-diabetic women in a nationwide study in Japan. In addition, the relationship between GDM and adverse pregnancy outcomes was also analyzed. MATERIALS AND

methodsThis cohort study (n = 89,799) used data from the Japan Environment and Children's Study. We stratified the participants into four groups according to HbA1c levels at an early stage of pregnancy. We investigated the association of HbA1c at an early stage of pregnancy with the risk of GDM, and of GDM with the risk of some representative adverse pregnancy outcomes, using the multiple logistic regression model with adjustment for potential confounders.

resultsThe adjusted odds ratio for GDM per 0.1 percentage point increase in HbA1c (%) was 1.20. The adjusted odds ratio for developing GDM was significantly increased in women from the HbA1c 5.0-5.4% category. GDM significantly increased the adjusted odds ratio for adverse pregnancy outcomes, such as hypertensive disorders of pregnancy, polyhydramnios and premature birth.

conclusionsHigh-normal HbA1c levels at the early stage of pregnancy are significantly associated with GDM risk in women in Japan. GDM was significantly associated with adverse pregnancy outcomes.

Indexed as

Diabetes, GestationalChildCohort StudiesFemaleGlycated HemoglobinHumansJapanPregnancyPregnancy OutcomeGlycated HemoglobinCohort studiesHyperglycemiaPregnancy outcome

Identifiers

PMID34679259
PMCPMC9017631
OpenAlexW3207418953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.