ArticleColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland2021
Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: results from the ColoREctal Wellbeing (CREW) study.
Article in Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- A Systematic Review of Trajectories of Clinically Relevant Distress Amongst Adults with Cancer: Course and Predictors.Journal of clinical psychology in medical settings · 2025Pooled it
- Global research trends on gastrointestinal cancer and mental health (2004-2024): a bibliographic study.Frontiers in medicine · 2025Pooled it
- The impact of sleep interventions combined with enhanced nutritional support on sleep quality, nutritional status, pain management, psychological well-being, and quality of life in postoperative colon cancer patients.Journal of cancer research and clinical oncology · 2025Trial
- Psychological Readiness for Surgery Through Prehabilitation and Treatment: A Longitudinal Qualitative Study.Psycho-oncology · 2026Article
- Quality of life, anxiety and depression risks after natural orifice specimen extraction surgery and conventional laparoscopic surgery for colorectal cancer patients: a prospective two-centre case-matched study.Surgical endoscopy · 2026Article
- Mapping of Preoperative Screening Tools Reveals Urgent Need for Standardization in Gastrointestinal Cancer Surgery: A Scoping Review.World journal of surgery · 2026Article
- Incidence of new-onset depression after colorectal cancer diagnosis and associated mortality: a population-based cohort study.BMJ oncology · 2026Article
- Optimizing postoperative recovery in colorectal cancer patients through integrated psychological and nutritional interventions.Journal of cancer survivorship : research and practice · 2025Article
- Social support, social constraint, and psychological adjustment in patients with colorectal cancer.Journal of behavioral medicine · 2025Article
- Factor analysis of postsurgical gastroparesis syndrome after right hemicolectomy for colon cancer.Oncology letters · 2025Article
- Body image as a mediator between bowel dysfunction symptoms and psychological outcomes among patients with colorectal cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Social Support, Depression and Anxiety in Cancer Patient-Relative Dyads in Early Survivorship: An Actor-Partner Interdependence Modeling Approach.Psycho-oncology · 2024Observational
- Current trends and hotspots of depressive disorders with colorectal cancer: A bibliometric and visual study.World journal of gastrointestinal oncology · 2024Article
- Article
- Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: results from the ColoREctal Wellbeing (CREW) study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021Article
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Authors and funding
12 authors at 3 institutions in 1 country.
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Abstract
aimDepression experienced by people with colorectal cancer (CRC) is an important clinical problem affecting quality of life. Recognition of depression at key points in the pathway enables timely referral to support. This study aimed to examine depression before and 5 years after surgery to examine its prevalence and identify determinants.
methodThe ColoREctal Wellbeing (CREW) study is a prospective UK cohort study involving 872 adults with nonmetastatic CRC recruited before surgery with curative intent. Questionnaires completed before surgery and 3, 9, 15, 24, 36, 48 and 60 months after surgery captured socio-demographics and assessed depression (Centre for Epidemiologic Studies Depression Scale, CES-D) and other psychosocial factors. Clinical details were also gathered. We present the prevalence of clinically significant depression (CES-D ≥ 20) over time and its predictors assessed before and 2 years after surgery.
resultsBefore surgery, 21.0% of the cohort reported CES-D ≥ 20 reducing to 14.7% 5 years after surgery. Presurgery risk factors predicting subsequent depression were clinically significant depression and anxiety, previous mental health service use, low self-efficacy, poor health, having neoadjuvant treatment and low social support. Postsurgery risk factors at 2 years predicting subsequent depression were clinically significant depression, negative affect, cognitive dysfunction, accommodation type and poor health.
conclusionDepression is highly pervasive in people with CRC, exceeding prevalence in the general population across follow-up. Our findings emphasize the need to screen and treat depression across the pathway. Our novel data highlight key risk factors of later depression at important and opportune time points: before surgery and at the end of routine surveillance. Early recognition and timely referral to appropriate support is vital to improve long-term psychological outcomes.
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