Evidence map›Paper›PMID 34679218›Full record

ArticleThe FEBS journal2022

Pseudoperoxidase activity, conformational stability, and aggregation propensity of the His98Tyr myoglobin variant: implications for the onset of myoglobinopathy.

Stefan Hofbauer, Marcello Pignataro, Marco Borsari, Carlo Augusto Bortolotti, Giulia Di Rocco, Gianina Ravenscroft, Paul G Furtmüller, Christian Obinger, Marco Sola, Gianantonio Battistuzzi

Open access · hybridAbstract read
In one paragraph

Article in The FEBS journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Stefan HofbauerDepartment of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria.ORCID 0000-0003-3375-7715
Marcello PignataroDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Italy.ORCID 0000-0003-0058-3659
Marco BorsariDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Italy.ORCID 0000-0002-3612-4764
Carlo Augusto BortolottiDepartment of Life Sciences, University of Modena and Reggio Emilia, Italy.ORCID 0000-0002-5701-5727
Giulia Di RoccoDepartment of Life Sciences, University of Modena and Reggio Emilia, Italy.ORCID 0000-0002-3187-2210
Gianina RavenscroftHarry Perkins Institute of Medical Research, Nedlands, WA, Australia.ORCID 0000-0003-3634-211X
Paul G FurtmüllerDepartment of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria.ORCID 0000-0002-1199-2469
Christian ObingerDepartment of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria.ORCID 0000-0002-7133-3430
Marco SolaDepartment of Life Sciences, University of Modena and Reggio Emilia, Italy.ORCID 0000-0002-2700-4154
Gianantonio BattistuzziDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Italy.ORCID 0000-0003-4716-5745
University of Modena and Reggio Emilia · ITBOKU University · ATThe University of Western Australia · AU

Funding

Austrian Science Fund FWF P 29099
6 · The paper itself

Abstract

The autosomal dominant striated muscle disease myoglobinopathy is due to the single point mutation His98Tyr in human myoglobin (MB), the heme protein responsible for binding, storage, and controlled release of O

Indexed as

HistidineHumansHydrogen PeroxideModels, MolecularMuscular DiseasesMutationMyoglobinProtein ConformationHistidineHydrogen PeroxideMyoglobinconformational stabilityheme bleachinghigh-molecular-weight aggregatesmyoglobinmyoglobinopathy

Identifiers

PMID34679218
PMCPMC9298411
OpenAlexW3207352680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.