Evidence map›Paper›PMID 34679201›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Labile Photo-Induced Free Radical in α-Ketoglutaric Acid: a Universal Endogenous Polarizing Agent for In Vivo Hyperpolarized

Adam P Gaunt, Jennifer S Lewis, Friederike Hesse, Tian Cheng, Irene Marco-Rius, Kevin M Brindle, Arnaud Comment

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Across-cities transportableNature communications · 2026
    Article
  2. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  3. Article
  4. Review
  5. New Horizons in HyperpolarizedMolecular imaging and biology · 2024
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Adam P GauntCancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.
Jennifer S LewisCancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.
Friederike HesseCancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.
Tian ChengCancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.
Irene Marco-RiusCancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.
Kevin M BrindleCancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.
Arnaud CommentCancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.ORCID 0000-0002-8484-3448
University of Cambridge · GBGeneral Electric (Spain) · ES

Funding

Cancer Research UK 17242Cancer Research UK 28289Cancer Research UK C9545/A29580European Research Council 682574
6 · The paper itself

Abstract

Hyperpolarized (HP)

Indexed as

Ketoglutaric AcidsAnimalsCarbon IsotopesFree RadicalsLiverMagnetic Resonance SpectroscopyPhotochemical ProcessesRatsCarbon-13Carbon IsotopesFree RadicalsKetoglutaric Acidsdynamic nuclear polarizationimaging agentsketo acidsmetabolismphotochemistry

Identifiers

PMID34679201
PMCPMC7612908
OpenAlexW3206199801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.