Evidence map›Paper›PMID 34679020›Full record

ArticleToxins2021

Natural Thiols, but Not Thioethers, Attenuate Patulin-Induced Endoplasmic Reticulum Stress in HepG2 Cells.

Hye Mi Kim, Hwa Young Choi, Gun Hee Cho, Ju Hee Im, Eun Young Hong, Hyang Sook Chun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hye Mi KimSchool of Food Science and Technology, Chung-Ang University, Anseong 17546, Korea.
Hwa Young ChoiSchool of Food Science and Technology, Chung-Ang University, Anseong 17546, Korea.
Gun Hee ChoSchool of Food Science and Technology, Chung-Ang University, Anseong 17546, Korea.
Ju Hee ImSchool of Food Science and Technology, Chung-Ang University, Anseong 17546, Korea.
Eun Young HongHK Inno. N Corporation, Eulji-ro, Jung-gu, Seoul 04551, Korea.
Hyang Sook ChunSchool of Food Science and Technology, Chung-Ang University, Anseong 17546, Korea.
Chung-Ang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patulin, a mycotoxin, is known to have cytotoxic effects, but few studies have focused on the involvement of the endoplasmic reticulum (ER) stress response in patulin toxicity and the natural compounds that attenuate it in HepG2 cells. This study tested the ability of patulin to induce ER stress, and that of four thiols and three thioethers to attenuate patulin-induced ER stress in HepG2 cells. Patulin dose-dependently inhibited cell proliferation (IC

Indexed as

Cell ProliferationEndoplasmic Reticulum StressGene Expression RegulationHep G2 CellsHumansPatulinSulfhydryl CompoundsSulfidesPatulinSulfhydryl CompoundsSulfidesER stressHepG2 cellsmycotoxinpatulinthiols

Identifiers

PMID34679020
PMCPMC8537938
OpenAlexW3205098856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.