Evidence map›Paper›PMID 34679019›Full record

ArticleToxins2021

Increased Risk of Thrombocytopenia and Death in Patients with Bacteremia Caused by High Alpha Toxin-Producing Methicillin-Resistant

Fatimah Alhurayri, Edith Porter, Rachid Douglas-Louis, Emi Minejima, Juliane Bubeck Wardenburg, Annie Wong-Beringer

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. The virulence toolkit of Staphylococcus aureus: a comprehensive review of toxin diversity, molecular mechanisms, and clinical implications.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Fatimah AlhurayriCollege of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Edith PorterCollege of Natural & Social Sciences, California State University Los Angeles, Los Angeles, CA 90032, USA.
Rachid Douglas-LouisSchool of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.
Emi MinejimaSchool of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.
Juliane Bubeck WardenburgSchool of Medicine, Washington University, St. Louis, MO 63130, USA.
Annie Wong-BeringerSchool of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0003-3302-1409
University of Southern California · USCalifornia State University Los Angeles · USWashington University in St. Louis · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
Role of Staphylococcus aureus alpha-hemolysin in diseaseR01AI097434 · NIAID · WASHINGTON UNIVERSITY · PI BUBECK WARDENBURG, JULIANE · 2012 to 2021
$4.0M
National Institute of Allergy and Infectious Diseases AI097434NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855NIAID NIH HHS R01 AI097434
6 · The paper itself

Abstract

Alpha toxin (Hla) is a major virulence factor of

Indexed as

AdultAgedBacteremiaBacterial ToxinsFemaleHemolysin ProteinsHumansMaleMethicillin-Resistant Staphylococcus aureusMiddle AgedRetrospective StudiesStaphylococcal InfectionsStaphylococcus aureusThrombocytopeniaBacterial ToxinsHemolysin Proteinsstaphylococcal alpha-toxinalpha toxinmortalityplateletsStaphylococcus aureus bacteremiathrombocytopeniavirulence factors

Identifiers

PMID34679019
PMCPMC8537302
OpenAlexW3205140874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.