Evidence map›Paper›PMID 34678525›Full record

ArticleHeart rhythm2022

Rotors anchored by refractory islands drive torsades de pointes in an experimental model of electrical storm.

Masatoshi Yamazaki, Naoki Tomii, Koichi Tsuneyama, Hiroki Takanari, Ryoko Niwa, Haruo Honjo, Itsuo Kodama, Tatsuhiko Arafune, Naomasa Makita, Ichiro Sakuma and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Abnormal CaFrontiers in pharmacology · 2025
    Article
  3. Mechanisms of torsades de pointes: an update.Frontiers in cardiovascular medicine · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

Masatoshi YamazakiDepartment of Cardiology, Nagano Hospital, Soja, Japan; Medical Device Development and Regulation Research Center, The University of Tokyo, Tokyo, Japan.
Naoki TomiiMedical Device Development and Regulation Research Center, The University of Tokyo, Tokyo, Japan; Department of Precision Engineering, The University of Tokyo, Tokyo, Japan.
Koichi TsuneyamaDepartment of Pathology and Laboratory Medicine, Institute of Post-LED Photonics, Tokushima University Faculty of Medicine, Tokushima, Japan.
Hiroki TakanariDepartment of Pathology and Laboratory Medicine, Institute of Post-LED Photonics, Tokushima University Faculty of Medicine, Tokushima, Japan.
Ryoko NiwaResearch Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Haruo HonjoResearch Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Itsuo KodamaResearch Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Tatsuhiko ArafuneSchool of Science and Engineering, Tokyo Denki University, Saitama, Japan.
Naomasa MakitaOmics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan.
Ichiro SakumaMedical Device Development and Regulation Research Center, The University of Tokyo, Tokyo, Japan; Department of Precision Engineering, The University of Tokyo, Tokyo, Japan.
Dobromir DobrevInstitute of Pharmacology, West German Heart and Vascular Center, University of Duisburg-Essen, Essen, Germany; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas; Departments of Medicine and Research Center, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Stanley NattelInstitute of Pharmacology, West German Heart and Vascular Center, University of Duisburg-Essen, Essen, Germany; Departments of Medicine and Research Center, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada; IHU LIYRC Institute, Bordeaux, France.
Yukiomi TsujiDepartment of Physiology of Visceral Function, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. Electronic address: yukiomitsuji@nagasaki-u.ac.jp.
Nagoya University · JPMontreal Heart Institute · CATokushima University · JPTokyo Medical University · JPNational Cerebral and Cardiovascular Center · JPTokyo Denki University · JPTokyo Medical University Hospital · JPUniversity of Nagasaki · JP

Funding

Ryanodine receptor regulation in post-operative atrial fibrillationR01HL089598 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2007 to 2022
$6.5M
The Role of Inflammasome in the Pathogenesis of Atrial FibrillationR01HL136389 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Na Li · 2017 to 2026
$5.6M
Sex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0M
CIHRNHLBI NIH HHS R01 HL089598NHLBI NIH HHS R01 HL131517NHLBI NIH HHS R01 HL136389
6 · The paper itself

Abstract

backgroundElectrical storm (ES) is a life-threatening emergency in patients at high risk of ventricular tachycardia/ventricular fibrillation (VF), but the pathophysiology and molecular basis are poorly understood.

objectiveThe purpose of this study was to explore the electrophysiological substrate for experimental ES.

methodsA model was created by inducing chronic complete atrioventricular block in defibrillator-implanted rabbits, which recapitulates QT prolongation, torsades des pointes (TdP), and VF episodes.

resultsOptical mapping revealed island-like regions with action potential duration (APD) prolongation in the left ventricle, leading to increased spatial APD dispersion, in rabbits with ES (defined as ≥3 VF episodes/24 h). The maximum APD and its dispersion correlated with the total number of VF episodes in vivo. TdP was initiated by an ectopic beat that failed to enter the island and formed a reentrant wave and perpetuated by rotors whose centers swirled in the periphery of the island. Epinephrine exacerbated the island by prolonging APD and enhancing APD dispersion, which was less evident after late Na

conclusionA tissue island with enhanced refractoriness contributes to the generation of drifting rotors that underlies ES in this model. Na

Indexed as

Action PotentialsAnimalsAtrioventricular BlockDefibrillators, ImplantableDisease Models, AnimalLong QT SyndromeRabbitsRanolazineTachycardia, VentricularTorsades de PointesRanolazineElectrical stormLate sodium currentNeuronal sodium channelRotorsTorsades de pointes

Identifiers

PMID34678525
PMCPMC8810573
OpenAlexW3206455975

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.