ArticleRespiratory physiology & neurobiology2022
Influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat.
Article in Respiratory physiology & neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Physiological mechanisms and therapeutic targets in chronic cough.Physiological reports · 2026Review
- The peripheral neuroimmune system.Journal of leukocyte biology · 2024Review
- Identifying vagal bronchopulmonary afferents mediating cough response to inhaled sulfur dioxide in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Neuroendocrine cells initiate protective upper airway reflexes.Science (New York, N.Y.) · 2024Article
- Hypotussic cough in persons with dysphagia: biobehavioral interventions and pathways to clinical implementation.Frontiers in rehabilitation sciences · 2024Review
- Chronic cough-the limitation and advances in assessment techniques.Journal of thoracic disease · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Recurrent laryngeal afferent fibers are primarily responsible for cough in response to mechanical or chemical stimulation of the upper trachea and larynx in the guinea pig. Lower airway slowly adapting receptors have been proposed to have a permissive effect on the cough reflex. We hypothesized that vagotomy below the recurrent laryngeal nerve branch would depress mechanically or chemically induced cough. In anesthetized, bilaterally thoracotomized, artificially ventilated cats, thoracic vagotomy nearly eliminated cough induced by mechanical stimulation of the intrathoracic airway, significantly depressed mechanically stimulated laryngeal cough, and eliminated capsaicin-induced cough. These results support an important role of lower airway sensory feedback in the production of tracheobronchial and laryngeal cough in the cat. Further, at least some of this feedback is due to excitation from pulmonary volume-sensitive sensory receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.