Evidence map›Paper›PMID 34678159›Full record

ArticleStructure (London, England : 1993)2022

Native state fluctuations in a peroxiredoxin active site match motions needed for catalysis.

Aidan B Estelle, Patrick N Reardon, Seth H Pinckney, Leslie B Poole, Elisar Barbar, P Andrew Karplus

Open access · greenAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Aidan B EstelleDepartment of Biochemistry and Biophysics, Oregon State University, 2011 ALS, Corvallis, OR 97331, USA.
Patrick N ReardonDepartment of Biochemistry and Biophysics, Oregon State University, 2011 ALS, Corvallis, OR 97331, USA; Oregon State University NMR Facility, Oregon State University, Corvallis, Oregon 97331, USA.
Seth H PinckneyDepartment of Biochemistry and Biophysics, Oregon State University, 2011 ALS, Corvallis, OR 97331, USA.
Leslie B PooleDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Elisar BarbarDepartment of Biochemistry and Biophysics, Oregon State University, 2011 ALS, Corvallis, OR 97331, USA. Electronic address: barbare@oregonstate.edu.
P Andrew KarplusDepartment of Biochemistry and Biophysics, Oregon State University, 2011 ALS, Corvallis, OR 97331, USA. Electronic address: andy.karplus@oregonstate.edu.
Oregon State University · USWake Forest University · US

Funding

Redox Regulation of Cysteine-Dependent Peroxidases and Signal Transduction PathwaysR35GM135179 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI POOLE, LESLIE B · 2020 to 2024
$1.9M
Mechanisms and Regulation of PeroxiredoxinsR01GM119227 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI POOLE, LESLIE B · 2016 to 2019
$1.4M
Acquisition of a 700 MHz NMR SpectrometerS10OD018518 · OD · OREGON STATE UNIVERSITY · PI BARBAR, ELISAR J · 2015 to 2015
$1.3M
NIGMS NIH HHS R01 GM119227NIGMS NIH HHS R35 GM135179NIH HHS S10 OD018518
6 · The paper itself

Abstract

Peroxiredoxins are ubiquitous enzymes that detoxify peroxides and regulate redox signaling. During catalysis, a "peroxidatic" cysteine (C

Indexed as

Amino Acid MotifsBacterial ProteinsCatalysisCatalytic DomainCrystallography, X-RayHydrogen BondingMagnetic Resonance SpectroscopyModels, MolecularPeroxiredoxinsProtein FoldingXanthomonas campestrisBacterial ProteinsPeroxiredoxinschemical exchange saturation transferenzyme catalysishydrogen exchangeModelfree Analysisnuclear magnetic resonance spectroscopyperoxiredoxinprotein dynamics

Identifiers

PMID34678159
PMCPMC8818020
OpenAlexW3205275961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.