Evidence map›Paper›PMID 34678064›Full record

ArticleScience advances2021

RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis.

Shu Zhang, Nadine Übelmesser, Natasa Josipovic, Giada Forte, Johan A Slotman, Michael Chiang, Henrike Johanna Gothe, Eduardo Gade Gusmao, Christian Becker, Janine Altmüller and 5 more

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed.

  1. Article
  2. Transcription and Three-Dimensional Genome Organization: Cause, Consequence, or Coordination?BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Many faces of mammalian NSD methyltransferases.Cellular & molecular biology letters · 2026
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Bridging spatial and temporal scales of developmental gene regulation.Current opinion in genetics & development · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Liquid condensates: a new barrier to loop extrusion?Cellular and molecular life sciences : CMLS · 2025
    Review

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shu ZhangInstitute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0001-5784-9564
Nadine ÜbelmesserInstitute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0003-3141-1526
Natasa JosipovicInstitute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0001-7683-0869
Giada ForteSchool of Physics and Astronomy, University of Edinburgh, EH9 3FD Edinburgh, UK.ORCID 0000-0001-9939-4465
Johan A SlotmanOptical Imaging Centre, Erasmus Medical Center, 3015 GD Rotterdam, Netherlands.ORCID 0000-0001-9705-9620
Michael ChiangSchool of Physics and Astronomy, University of Edinburgh, EH9 3FD Edinburgh, UK.ORCID 0000-0002-1620-2550
Henrike Johanna GotheInstitute of Molecular Biology, 55128 Mainz, Germany.ORCID 0000-0003-0093-8077
Eduardo Gade GusmaoInstitute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Christian BeckerCologne Center for Genomics, University of Cologne, 50931 Cologne, Germany.
Janine AltmüllerCologne Center for Genomics, University of Cologne, 50931 Cologne, Germany.ORCID 0000-0003-4372-1521
Adriaan B HoutsmullerOptical Imaging Centre, Erasmus Medical Center, 3015 GD Rotterdam, Netherlands.
Vassilis RoukosInstitute of Molecular Biology, 55128 Mainz, Germany.ORCID 0000-0002-5065-3937
Kerstin S WendtDepartment of Cell Biology, Erasmus Medical Center, 3015 GD Rotterdam, Netherlands.ORCID 0000-0003-0235-1237
Davide MarenduzzoSchool of Physics and Astronomy, University of Edinburgh, EH9 3FD Edinburgh, UK.
Argyris PapantonisInstitute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0001-7551-1073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammalian chromosomes are three-dimensional entities shaped by converging and opposing forces. Mitotic cell division induces marked chromosome condensation, but following reentry into the G

Identifiers

PMID34678064
PMCPMC8535795

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.