ArticleScience advances2021
Structural basis for selective modification of Rho and Ras GTPases by
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed.
- Modeling Clostridioides difficile toxin pathogenesis and antiserum protection in an immunocompetent intestine-on-chip platform.Scientific reports · 2026Article
- An evolutionarily conserved salt bridge stabilizes the active site for GTP hydrolysis in Rho GTPases.The Journal of biological chemistry · 2026Article
- Development of Peptide Glucosyltransferase Inhibitors With Comprehensive Coverage Across Clostridioides difficile Toxin B Sub-Types.Biotechnology and bioengineering · 2026Article
- The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice.PLoS pathogens · 2025Article
- Kinetic Mechanism of the Emergent Anticancer Target, Human ADP-ribosyltransferase 1.Biochemistry · 2025Article
- AgainstToxins · 2025Review
- Comprehensive review ofWorld journal of gastrointestinal pharmacology and therapeutics · 2025Article
- Mechanisms ofFrontiers in cellular and infection microbiology · 2025Review
- Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation.Cell discovery · 2024Article
- Review
- Exploring the Toxin-Mediated Mechanisms inMicroorganisms · 2024Review
- Article
- Receptor binding mechanisms of Clostridioides difficile toxin B and implications for therapeutics development.The FEBS journal · 2023Review
- Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants.Nature communications · 2022Article
- Article
- Structure and conformational dynamics ofLife science alliance · 2022Article
- Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition.Scientific reports · 2022Article
- TcdB ofInternational journal of molecular sciences · 2022Article
- Neutralizing epitopes onFrontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Zheng LiuDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-6842-6273
Sicai ZhangDepartment of Urology, Boston Children's Hospital, and Departments of Microbiology and Surgery, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8894-5476
Peng ChenDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-6356-7683
Songhai TianDepartment of Urology, Boston Children's Hospital, and Departments of Microbiology and Surgery, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6630-1904
Ji ZengDepartment of Urology, Boston Children's Hospital, and Departments of Microbiology and Surgery, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8770-3048
Kay PerryNE-CAT and Department of Chemistry and Chemical Biology, Cornell University, Argonne National Laboratory, Lemont, IL 60439, USA.ORCID 0000-0002-4046-1704
Min DongDepartment of Urology, Boston Children's Hospital, and Departments of Microbiology and Surgery, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1744-7293
Rongsheng JinDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-0348-7363
Funding
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI MALCOLM S. CAPEL · 2018 to 2026
$34.2MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4MStructure and Function of C. Difficile ToxinsR01AI139087 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Min Dong, Rongsheng Jin · 2018 to 2026
$7.4MLong-term effects of botulinum neurotoxins on neuronal viabilityR01NS080833 · NINDS · HARVARD MEDICAL SCHOOL · PI Min Dong · 2013 to 2026
$6.8MMolecular basis of action and pathogenesis of Clostridium difficile toxin BR01AI132387 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DONG, MIN · 2017 to 2021
$3.5MMolecular mechanisms of botulinum neurotoxin neutralizationR01AI125704 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG, SHOEMAKER, CHARLES BIX · 2016 to 2020
$3.0MPixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0MComputational design of inhibitors against botulinum neurotoxinR21AI139690 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2018 to 2019
$440kStructural basis of Rho glucosylation by Clostridium difficile toxinsR21AI156092 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2021 to 2022
$432kStructural mechanism for recognition of host receptor by botulinum neurotoxin AR21AI123920 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2016 to 2017
$425kNovel anti-cancer biologics targeting Wnt signaling pathwayR21CA235533 · NCI · BOSTON CHILDREN'S HOSPITAL · PI DONG, MIN, JIN, RONGSHENG · 2019 to 2020
$413kNCI NIH HHS R21 CA235533NIAID NIH HHS R01 AI125704NIAID NIH HHS R01 AI132387NIAID NIH HHS R01 AI139087NIAID NIH HHS R21 AI123920NIAID NIH HHS R21 AI139690NIAID NIH HHS R21 AI156092NICHD NIH HHS P50 HD105351NIGMS NIH HHS P30 GM124165NIH HHS S10 OD021527NINDS NIH HHS R01 NS080833
Abstract
Toxin B (TcdB) is a primary cause of
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.