Evidence map›Paper›PMID 34677943›Full record

ReviewChemical reviews2022

Dissecting Biological and Synthetic Soft-Hard Interfaces for Tissue-Like Systems.

Yin Fang, Xiao Yang, Yiliang Lin, Jiuyun Shi, Aleksander Prominski, Clementene Clayton, Ellie Ostroff, Bozhi Tian

Abstract readReview
In one paragraph

Review in Chemical reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yin FangThe James Franck Institute, University of Chicago, Chicago, Illinois 60637, United States.
Xiao YangDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.
Yiliang LinThe James Franck Institute, University of Chicago, Chicago, Illinois 60637, United States.
Jiuyun ShiThe James Franck Institute, University of Chicago, Chicago, Illinois 60637, United States.
Aleksander ProminskiThe James Franck Institute, University of Chicago, Chicago, Illinois 60637, United States.
Clementene ClaytonDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637, United States.
Ellie OstroffDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637, United States.
Bozhi TianThe James Franck Institute, University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0003-0593-0023

Funding

Silicon-based Injectable Micro-gels for Non-genetic and Wireless Modulation of Neurons, Cardiomyocytes and Neuromuscular SystemDP2NS101488 · NINDS · UNIVERSITY OF CHICAGO · PI TIAN, BOZHI · 2016 to 2016
$2.4M
NINDS NIH HHS DP2 NS101488
6 · The paper itself

Abstract

Soft and hard materials at interfaces exhibit mismatched behaviors, such as mismatched chemical or biochemical reactivity, mechanical response, and environmental adaptability. Leveraging or mitigating these differences can yield interfacial processes difficult to achieve, or inapplicable, in pure soft or pure hard phases. Exploration of interfacial mismatches and their associated (bio)chemical, mechanical, or other physical processes may yield numerous opportunities in both fundamental studies and applications, in a manner similar to that of semiconductor heterojunctions and their contribution to solid-state physics and the semiconductor industry over the past few decades. In this review, we explore the fundamental chemical roles and principles involved in designing these interfaces, such as the (bio)chemical evolution of adaptive or buffer zones. We discuss the spectroscopic, microscopic, (bio)chemical, and computational tools required to uncover the chemical processes in these confined or hidden soft-hard interfaces. We propose a soft-hard interaction framework and use it to discuss soft-hard interfacial processes in multiple systems and across several spatiotemporal scales, focusing on tissue-like materials and devices. We end this review by proposing several new scientific and engineering approaches to leveraging the soft-hard interfacial processes involved in biointerfacing composites and exploring new applications for these composites.

Indexed as

Semiconductors

Identifiers

PMID34677943
PMCPMC8917063

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.