Evidence map›Paper›PMID 34677927›Full record

ReviewAccounts of chemical research2021

Development of Integrated Systems for On-Site Infection Detection.

Chang Yeol Lee, Ismail Degani, Jiyong Cheong, Ralph Weissleder, Jae-Hyun Lee, Jinwoo Cheon, Hakho Lee

Open access · greenAbstract readReview
In one paragraph

Review in Accounts of chemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Electrochemical Immunodetection ofSensors (Basel, Switzerland) · 2025
    Article
  3. [Evaluation of Gradient-Variant Quantum Dot Fluorescence Technology for Rapid Detection ofSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Article
  4. Article
  5. Review
  6. Positron Emission Tomography Imaging ofACS infectious diseases · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Chang Yeol LeeCenter for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge Street, Boston, Massachusetts 02114, United States.ORCID 0000-0001-5382-8635
Ismail DeganiCenter for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge Street, Boston, Massachusetts 02114, United States.ORCID 0000-0001-6210-1200
Jiyong CheongInstitute for Basic Science (IBS), Center for NanoMedicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.ORCID 0000-0001-6652-9394
Ralph WeisslederCenter for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge Street, Boston, Massachusetts 02114, United States.ORCID 0000-0003-0828-4143
Jae-Hyun LeeInstitute for Basic Science (IBS), Center for NanoMedicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.ORCID 0000-0002-9236-157X
Jinwoo CheonInstitute for Basic Science (IBS), Center for NanoMedicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.ORCID 0000-0001-8948-5929
Hakho LeeCenter for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge Street, Boston, Massachusetts 02114, United States.ORCID 0000-0002-0087-0909
Harvard University · USYonsei University · KRVassar College · US

Funding

Early Detection through Novel OCEAN Technology - Ovarian Cancer Exosomal Analysis with NanoplasmonicsU01CA233360 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CASTRO, CESAR M, DINULESCU, DANIELA M · 2018 to 2022
$3.5M
Clinical platform for high-throughput analyses of extracellular vesiclesR01CA229777 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO, SKOG, JOHAN · 2018 to 2022
$3.2M
Imaging and Liquid Biopsy for Glioma Diagnosis and Treatment MonitoringR01CA239078 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BALAJ, LEONORA, LEE, HAKHO · 2020 to 2024
$3.1M
Standardized Molecular Analyses of Glioma EVsR01CA237500 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CARTER, BOB S, LEE, HAKHO · 2020 to 2024
$3.0M
High-throughput Integrated Magneto-electrochemical Exosome (HiMEX) platform to identify neurodevelopmental markers associated with pre and postnatal oxycodone exposureR21DA049577 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO, PENDYALA, GURUDUTT · 2019 to 2020
$458k
NCI NIH HHS R01 CA229777NCI NIH HHS R01 CA237500NCI NIH HHS R01 CA239078NCI NIH HHS U01 CA233360NIDA NIH HHS R21 DA049577
6 · The paper itself

Abstract

The modern healthcare system faces an unrelenting threat from microorganisms, as evidenced by global outbreaks of new viral diseases, emerging antimicrobial resistance, and the rising incidence of healthcare-associated infections (HAIs). An effective response to these threats requires rapid and accurate diagnostic tests that can identify causative pathogens at the point of care (POC). Such tests could eliminate diagnostic uncertainties, facilitating patient triaging, minimizing the empiric use of antimicrobial drugs, and enabling targeted treatments. Current standard methods, however, often fail to meet the needs of rapid diagnosis in POC settings. Culture-based assays entail long processing times and require specialized laboratory infrastructure; nucleic acid (NA) tests are often limited to centralized hospitals due to assay complexity and high costs. Here we discuss two new POC tests developed in our groups to enable the rapid diagnosis of infection. The first is nanoPCR that takes advantages of core-shell magnetoplasmonic nanoparticles (MPNs): (i) Au shell significantly accelerates thermocycling via volumetric, plasmonic light-to-heat conversion and (ii) a magnetic core enables sensitive

Indexed as

COVID-19 TestingFluorescence PolarizationNanotechnologyPolymerase Chain ReactionBacterial InfectionsCOVID-19Fluorescent DyesHumansPoint-of-Care SystemsRNA, ViralSARS-CoV-2Fluorescent DyesRNA, Viral

Identifiers

PMID34677927
PMCPMC9099220
OpenAlexW3207507780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.