Evidence map›Paper›PMID 34677821›Full record

ArticleJournal of clinical monitoring and computing2022

Indirect measurement of absolute cardiac output during exercise in simulated altered gravity is highly dependent on the method.

Richard S Whittle, Lindsay M Stapleton, Lonnie G Petersen, Ana Diaz-Artiles

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Article in Journal of clinical monitoring and computing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Richard S WhittleDepartment of Aerospace Engineering, Texas A&M University, 3141 TAMU, College Station, TX, 77843, USA.ORCID 0000-0002-7437-5433
Lindsay M StapletonDepartment of Aerospace Engineering, Texas A&M University, 3141 TAMU, College Station, TX, 77843, USA.ORCID 0000-0002-7743-2800
Lonnie G PetersenDepartment of Radiology, University of California San Diego, 8929 University Center Lane, La Jolla, CA, 92122, USA.ORCID 0000-0002-5155-9651
Ana Diaz-ArtilesDepartment of Aerospace Engineering, Texas A&M University, 3141 TAMU, College Station, TX, 77843, USA. adartiles@tamu.edu.ORCID 0000-0002-0459-9327

Funding

national aeronautics and space administration 80NSSC19K0020national aeronautics and space administration 80NSSC20K1521
6 · The paper itself

Abstract

purposeAltered gravity environments introduce cardiovascular changes that may require continuous hemodynamic monitoring in both spaceflight and terrestrial analogs. Conditions in such environments are often prohibitive to direct/invasive methods and therefore, indirect measurement techniques must be used. This study compares two common cardiac measurement techniques used in the human spaceflight domain, pulse contour analysis (PCA-Nexfin) and inert gas rebreathing (IGR-Innocor), in subjects completing ergometer exercise under altered gravity conditions simulated using a tilt paradigm.

methodsSeven subjects were tilted to three different angles representing Martian, Lunar, and microgravity conditions in the rostrocaudal direction. They completed a 36-min submaximal cardiovascular exercise protocol in each condition. Hemodynamics were continuously monitored using Nexfin and Innocor.

resultsLinear mixed-effects models revealed a significant bias of [Formula: see text] ml ([Formula: see text]) in stroke volume and [Formula: see text] l/min ([Formula: see text]) in cardiac output, with Nexfin measuring greater than Innocor in both variables. These values are in agreement with a Bland-Altman analysis. The correlation of stroke volume and cardiac output measurements between Nexfin and Innocor were [Formula: see text] ([Formula: see text]) and [Formula: see text] ([Formula: see text]) respectively.

conclusionThere is a poor agreement in absolute stroke volume and cardiac output values between measurement via PCA (Nexfin) and IGR (Innocor) in subjects who are exercising in simulated altered gravity environments. These results suggest that the chosen measurement method and device greatly impacts absolute measurements of cardiac output. However, there is a good level of agreement between the two devices when measuring relative changes. Either of these devices seem adequate to capture cardiac changes, but should not be solely relied upon for accurate measurement of absolute cardiac output.

Indexed as

Extraterrestrial EnvironmentMarsCardiac OutputExerciseExercise TestHumansAltered gravityCardiac outputInert gas rebreathingInnocorNexfinPulse contour analysis

Identifiers

PMID34677821

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.