ArticleInternational ophthalmology2022
Ability of non-invasive tear break-up time to determine tear instability in contact lens wearers.
Article in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Determination of the Non-Invasive Tear Break-Up Time Cut-Off Point for Diagnosis of Dry Eye Disease and Its Correlation with Other Dry Eye Tests.Turkish journal of ophthalmology · 2026Article
- Fluorescein tear breakup time predicts pre-lens tear film stability and contact lens comfort.Journal of the Chinese Medical Association : JCMA · 2026Article
- Changes in Corneal Epithelial Thickness and Tear Film Stability After Carboxymethyl Cellulose Use in Young Adults with High Screen Time Exposure.Clinical optometry · 2026Article
- Dry eye after photorefractive keratectomy (PRK) and transepithelial photorefractive keratectomy (T-PRK): a comparative clinical study.International ophthalmology · 2025Observational
- Overview of Dry Eye Disease for Primary Care Physicians.Medicina (Kaunas, Lithuania) · 2025Review
- Pre-Lens Tear Meniscus Height, Lipid Layer Pattern and Non-Invasive Break-Up Time Short-Term Changes with a Water Gradient Silicone Hydrogel Contact Lens.Life (Basel, Switzerland) · 2022Article
- Changes in Noncontact Meibography and Noninvasive Tear Break-Up Time Test with Contact Lenses Usage.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Progress of Bulbar Conjunctival Microcirculation Alterations in the Diagnosis of Ocular Diseases.Disease markers · 2022Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the performance of precorneal and prelens non-invasive tear break-up time (NIBUT) measurements to determine tear instability in contact lens (CL) wearers.
methodsIn this study, 50 eyes of 25 CL wearers were evaluated. Precorneal first and average NIBUTs and fluorescein tear break-up time (FBUT) were measured before wearing CLs in the morning. Those with FBUT less than 10 s were considered to have tear instability. After wearing CL, first and average prelens NIBUTs were measured at the 30th minute. The receiver operating characteristic (ROC) curve was analyzed to evaluate the performance of NIBUT measurements in the diagnosis of tear instability.
resultsThe FBUT value had a significant correlation with first and average precorneal NIBUT values (p < 0.001, r = 0.653 and p < 0.001, r = 0.628, respectively). The FBUT value had no correlation with the prelens first and average NIBUT values (p = 0.542 and p = 0.263, respectively). To understand the relationship between the precorneal and prelens NIBUT values measured by the automated method, their correlation was evaluated. There was no significant correlation between the precorneal and prelens NIBUTs (for all; p > 0.05). The area under curve (AUC) in ROC curve for the first and average precorneal NIBUTs were 0.842 (p < 0.001) and 0.810 (p < 0.001), respectively. The AUC values for the first and average prelens NIBUTs at the 30th minute of CL wear were 0.586 and 0.619, respectively (p = 0.317 and p = 0.166, respectively).
conclusionsPrecorneal NIBUT measurements may be useful in diagnosing tear instability. Prelens NIBUT values are not yet capable of adequately defining the tear film dynamics in CL wearers.
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