Evidence map›Paper›PMID 34677720›Full record

ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2021

Diagnostic criteria for initial orthostatic hypotension: a narrative review.

Daan J L van Twist, Mark P M Harms, Veera K van Wijnen, Victoria E Claydon, Roy Freeman, William P Cheshire, Wouter Wieling

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. A Closed-Loop Cardiovascular Model of the Supine-To-Stand Manoeuvre: Implications for Falls.International journal for numerical methods in biomedical engineering · 2026
    Article
  3. Article
  4. Understanding measurement of postural hypotension: a nationwide survey of general practice in England.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daan J L van TwistDepartment of Internal Medicine, Zuyderland Medical Centre, PO-box 5500, 6130 MB, Sittard, The Netherlands. d.vantwist@zuyderland.nl.ORCID 0000-0001-8433-8030
Mark P M HarmsDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Veera K van WijnenDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Victoria E ClaydonDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.
Roy FreemanCenter for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
William P CheshireDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Wouter WielingDepartment of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormalities in orthostatic blood pressure changes upon active standing are associated with morbidity, mortality, and reduced quality of life. However, over the last decade, several population-based cohort studies have reported a remarkably high prevalence (between 25 and 70%) of initial orthostatic hypotension (IOH) among elderly individuals. This has raised the question as to whether the orthostatic blood pressure patterns in these community-dwelling elderly should truly be considered as pathological. If not, redefining of the systolic cutoff values for IOH (i.e., a value ≥ 40 mmHg in systolic blood pressure in the first 15 s after standing up) might be necessary to differ between normal aging and true pathology. Therefore, in this narrative review, we provide a critical analysis of the current reference values for the changes in systolic BP in the first 60 s after standing up and discuss how these values should be applied to large population studies. We will address factors that influence the magnitude of the systolic blood pressure changes following active standing and the importance of standardization of the stand-up test, which is a prerequisite for quantitative, between-subject comparisons of the postural hemodynamic response.

Indexed as

Hypotension, OrthostaticAgedBlood PressureBlood Pressure DeterminationHemodynamicsHumansQuality of LifeInitial orthostatic hypotensionOrthostatic hypotensionPostural blood pressure changes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.