Evidence map›Paper›PMID 34677712›Full record

ArticleMolecular biology reports2021

Genetic polymorphisms in the miR-372 (rs12983273) and LncRNA HULC (rs7763881) genes and susceptibility to Hepatitis B virus (HBV) infection.

Samar M Shahen, Sohi Z Elshenawy, Salwa E Mohamed, Robe M Talaat

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Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. LncRNA CKMT2-AS1 Promotes Hepatocellular Carcinoma Development Via Sponging miR-142-5p and Targeting IFITM3.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Samar M ShahenMolecular Biology Department, Genetic Engineering, and Biotechnology Research Institute (GEBRI), University of Sadat City (USC), Sadat City, 32958, Egypt.
Sohi Z ElshenawyClinical Biochemistry and Molecular Diagnostics Department, National Liver Institute, Menoufia University, Shebin Al-Kom, Egypt.
Salwa E MohamedMolecular Biology Department, Genetic Engineering, and Biotechnology Research Institute (GEBRI), University of Sadat City (USC), Sadat City, 32958, Egypt.
Robe M TalaatMolecular Biology Department, Genetic Engineering, and Biotechnology Research Institute (GEBRI), University of Sadat City (USC), Sadat City, 32958, Egypt. roba.talaat@gebri.usc.edu.eg.ORCID http://orcid.org/0000-0002-1176-2727
University of Sadat City · EGMenoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicroRNAs (miRNAs) and Long non-coding RNAs (lncRNAs) are two major types of non-coding RNAs (ncRNAs) with regulatory roles. The initiation and progression of numerous diseases have been linked to genetic variation in miRNAs and lncRNAs. Many diseases, including hepatitis infection, are thought to be regulated by miRNA-LncRNA interactions. In this study, Single nucleotide polymorphisms (SNPs) in miR-372 (rs28461391 C/T) and HULC (rs7763881 A/C) were believed to play a role in HBV infection risk. METHODS AND

resultsUsing the Polymerase chain reaction sequence-specific primer technique (PCR-SSP), 100 HBV patients and 100 healthy controls were genotyped for SNPs rs28461391 in miR-372 and rs7763881 in HULC. There was no significant difference in miR-372 rs12983273 genotype distribution between controls and HBV patients, according to our findings. On the other hand, there was a significant increase in HULC rs7763881 CC genotype (P < 0.05) coincides with a significant decrease in AC genotype distribution (P < 0.05) in HBV patients as compared to controls. Our results showed that the AA genotype is protective for HBV infection (OR 0.3; CI 0.13-9.07) while the CC genotype is associated with an increased risk of HBV infection (OR 3.43; CI 1.3-9.07).

conclusionsOur results suggest that HULC rs7763881 A/C might be a biomarker for HBV susceptibility. Larger sample studies are needed to confirm our preliminary data. To the best of our knowledge, the present study was the first to investigate the relevance of miR-372 (rs28461391 C/T) and HULC (rs7763881 A/C) gene polymorphisms to the risk of HBV infection in the Egyptian population.

Indexed as

AdultAllelesEgyptFemaleGenetic Predisposition to DiseaseGenotypeHepatitis BHepatitis B virusHumansMaleMicroRNAsMiddle AgedPolymorphism, Single NucleotideRNA, Long NoncodingHULC long non-coding RNA, humanMicroRNAsMIRN372 microRNA, humanRNA, Long NoncodingHBVHULCmiR-372PolymorphismSNP

Identifiers

PMID34677712
OpenAlexW3206085209

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.