ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2022
Localisation of cryptochrome 2 in the avian retina.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Protocol for whole-brain immunolabeling, clearing, and light-sheet imaging of C-FOS in the pigeon.STAR protocols · 2026Article
- Cryptochrome 4b protein is probably irrelevant for radical pair-based magnetoreception in the European robin.Journal of the Royal Society, Interface · 2025Article
- Full-Length Cryptochrome 1 in the Outer Segments of the Retinal Blue Cone Photoreceptors in Humans and Great Apes Suggests a Role Beyond Transcriptional Repression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- European Robin Cryptochrome-4a Associates with Lipid Bilayers in an Ordered Manner, Fulfilling a Molecular-Level Condition for Magnetoreception.ACS chemical biology · 2025Article
- Importance of Polarizable Embedding for Absorption Spectrum Calculations ofThe journal of physical chemistry. B · 2024Article
- Dimerization of European Robin Cryptochrome 4a.The journal of physical chemistry. B · 2023Article
- Upper bound for broadband radiofrequency field disruption of magnetic compass orientation in night-migratory songbirds.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Morphology, biochemistry and connectivity of Cluster N and the hippocampal formation in a migratory bird.Brain structure & function · 2022Article
- Double cones in the avian retina form an oriented mosaic which might facilitate magnetoreception and/or polarized light sensing.Journal of the Royal Society, Interface · 2022Article
- Broadband 75-85 MHz radiofrequency fields disrupt magnetic compass orientation in night-migratory songbirds consistent with a flavin-based radical pair magnetoreceptor.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- Magnetosensation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Cryptochromes are photolyase-related blue-light receptors acting as core components of the mammalian circadian clock in the cell nuclei. One or more members of the cryptochrome protein family are also assumed to play a role in avian magnetoreception, but the primary sensory molecule in the retina of migratory birds that mediates light-dependent magnetic compass orientation has still not been identified. The mRNA of cryptochrome 2 (Cry2) has been reported to be located in the cell nuclei of the retina, but Cry2 localisation has not yet been demonstrated at the protein level. Here, we provide evidence that Cry2 protein is located in the photoreceptor inner segments, the outer nuclear layer, the inner nuclear layer and the ganglion cell layer in the retina of night-migratory European robins, homing pigeons and domestic chickens. At the subcellular level, we find Cry2 both in the cytoplasm and the nucleus of cells residing in these layers. This broad nucleic expression rather points to a role for avian Cry2 in the circadian clock and is consistent with a function as a transcription factor, analogous to mammalian Cry2, and speaks against an involvement in magnetoreception.
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