Evidence map›Paper›PMID 34677626›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Lei Kang, Cuicui Li, Qi Yang, Logan Sutherlin, Lin Wang, Zhao Chen, Kaelyn V Becker, Nan Huo, Yongkang Qiu, Jonathan W Engle and 5 more

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06385652 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Clinical PET Imaging Evaluation of 68Ga-NB381 Probe in Multiple Myeloma

TypeinterventionalSponsorPeking University First HospitalRan2024 to 2026Enrolled30ConditionsMultiple MyelomaArms68Ga-NB381
NCT06717113 early_phase1recruitingnot on this mapstarted 2025, after this paper: background citation

Clinical PET Imaging Evaluation of 68Ga-BC1 Probe in Multiple Myeloma

TypeinterventionalSponsorPeking University First HospitalRan2025 to 2028Enrolled50ConditionsMultiple Myeloma and Malignant Plasma Cell NeoplasmsArms18F-FDG, 68Ga-BC1
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  4. Review
  5. Article
  6. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
  7. Theranostic role ofEuropean journal of nuclear medicine and molecular imaging · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. CD38-specific nanobodies allowFrontiers in immunology · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Lei KangDepartment of Nuclear Medicine, Peking University First Hospital, Xicheng Dist, No. 8 Xishiku Str, Beijing, 100034, China. kanglei@bjmu.edu.cn.
Cuicui LiDepartment of Nuclear Medicine, Peking University First Hospital, Xicheng Dist, No. 8 Xishiku Str, Beijing, 100034, China.
Qi YangDepartment of Nuclear Medicine, Peking University First Hospital, Xicheng Dist, No. 8 Xishiku Str, Beijing, 100034, China.
Logan SutherlinDepartments of Radiology and Medical Physics, University of Wisconsin - Madison, K6/562 Clinical Science Center, 600 Highland Ave, Madison, WI, 53705-2275, USA.
Lin WangBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Zhao ChenDepartment of Nuclear Medicine, Peking University First Hospital, Xicheng Dist, No. 8 Xishiku Str, Beijing, 100034, China.
Kaelyn V BeckerDepartments of Radiology and Medical Physics, University of Wisconsin - Madison, K6/562 Clinical Science Center, 600 Highland Ave, Madison, WI, 53705-2275, USA.
Nan HuoDepartment of Medical Molecular Biology, Beijing Institute of Biotechnology, 27 Tai-Ping Rd, Beijing, 100850, China.
Yongkang QiuDepartment of Nuclear Medicine, Peking University First Hospital, Xicheng Dist, No. 8 Xishiku Str, Beijing, 100034, China.
Jonathan W EngleDepartments of Radiology and Medical Physics, University of Wisconsin - Madison, K6/562 Clinical Science Center, 600 Highland Ave, Madison, WI, 53705-2275, USA.
Rongfu WangDepartment of Nuclear Medicine, Peking University First Hospital, Xicheng Dist, No. 8 Xishiku Str, Beijing, 100034, China.
Chengzhi HeBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Dawei JiangDepartments of Radiology and Medical Physics, University of Wisconsin - Madison, K6/562 Clinical Science Center, 600 Highland Ave, Madison, WI, 53705-2275, USA. daweijiang@hust.edu.cn.
Xiaojie XuDepartment of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China. miraclexxj@126.com.
Weibo CaiDepartments of Radiology and Medical Physics, University of Wisconsin - Madison, K6/562 Clinical Science Center, 600 Highland Ave, Madison, WI, 53705-2275, USA. wcai@uwhealth.org.
Peking University · CNUniversity of Wisconsin–Madison · USBeijing University of Chemical Technology · CNHuazhong University of Science and Technology · CNPeking University First Hospital · CN

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
NCI NIH HHS P30 CA014520
6 · The paper itself

Abstract

purposeAbnormal CD38 expression in some hematologic malignancies, including lymphoma, has made it a biomarker for targeted therapies. Daratumumab (Dara) is the first FDA-approved CD38-specific monoclonal antibody, enabling successfully immunoPET imaging over the past years. Radiolabeled Dara however has a long blood circulation and delayed tumor uptake which can limit its applications. The focus of this study is to develop

methodsF(ab')

resultsFlow cytometry and SPR assay proved the specific binding ability of Dara-F(ab')

conclusions[

Indexed as

Antibodies, MonoclonalLymphomaAnimalsCell Line, TumorHumansImmunoglobulin Fab FragmentsImmunoglobulin GPositron-Emission TomographyAntibodies, MonoclonaldaratumumabImmunoglobulin Fab FragmentsImmunoglobulin GCD38Cu-64DaratumumabF(ab′)2ImmunoPETLymphoma

Identifiers

PMID34677626
PMCPMC8940612
OpenAlexW3207198864

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.