GuidelineIntensive care medicine2021
Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine.
Guideline in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Guideline
- Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review.Critical care (London, England) · 2023Pooled it
- Transfusion strategies in bleeding critically ill adults: A clinical practice guideline from the European Society of Intensive Care Medicine: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine.Acta anaesthesiologica Scandinavica · 2022Guideline
- Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial.Military Medical Research · 2024Trial
- Association of initial lactate levels and red blood cell transfusion strategy with outcomes after severe trauma: a post hoc analysis of the RESTRIC trial.World journal of emergency surgery : WJES · 2024Trial
- Prediction of Blood Transfusion Need and Dose in Patients With Upper Gastrointestinal Bleeding: Retrospective Multicenter Prediction Model Study.JMIR medical informatics · 2026Article
- Embracing complexity in transfusion research.Vox sanguinis · 2026Review
- Bridging the gap between physiology and transfusion guidelines: do we treat hemoglobin or patients?Intensive care medicine · 2026Article
- ICU Clinicians' View on Platelet Transfusion Thresholds for a Future Trial-Protocol for an International Survey.Acta anaesthesiologica Scandinavica · 2026Article
- Red Blood Cell Transfusion Beyond Restrictive Thresholds in Patients With Septic Shock and an Elevated Lactate Level: A Multicenter Observational Study.Journal of Korean medical science · 2026Observational
- Clinical Outcomes and Safety Profile of Tranexamic Acid Use in Critically Ill Patients with Bleeding: A Single-Center Retrospective Descriptive Study.Healthcare (Basel, Switzerland) · 2026Article
- Machine learning based prediction of platelet concentration from ROTEM measurements.Scientific reports · 2026Article
- Optimal fibrinogen threshold in non-traumatic massive bleeding: a multicenter retrospective observational study.Critical care (London, England) · 2026Observational
- Major haemorrhage and blood product utilisation in patients receiving VA ECMO for cardiogenic shock: a multicentre observational study (OBLEX).Critical care (London, England) · 2026Observational
- Multiomic analyses of longitudinal plasma samples identify thromboinflammation endotypes and trajectories in patients with trauma.Science translational medicine · 2026Article
- Physiological determinants and the red blood cells transfusion decision-making process in non-bleeding critically ill patients: a comprehensive narrative review.Intensive care medicine · 2026Review
- Opportunities for improving platelet transfusion practice: A large retrospective audit across 22 hospitals.British journal of haematology · 2026Article
- Sex and gender differences in hemostasis in critical illness.Critical care science · 2026Review
- Molecular Mechanisms of Transfusion-Associated Immunomodulation and Its Impact in the Critically Ill.International journal of molecular sciences · 2025Review
- Postresuscitation platelet transfusion in major trauma patients.Transfusion · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
Abstract
purposeTo develop evidence-based clinical practice recommendations regarding transfusion practices and transfusion in bleeding critically ill adults.
methodsA taskforce involving 15 international experts and 2 methodologists used the GRADE approach to guideline development. The taskforce addressed three main topics: transfusion support in massively and non-massively bleeding critically ill patients (transfusion ratios, blood products, and point of care testing) and the use of tranexamic acid. The panel developed and answered structured guideline questions using population, intervention, comparison, and outcomes (PICO) format.
resultsThe taskforce generated 26 clinical practice recommendations (2 strong recommendations, 13 conditional recommendations, 11 no recommendation), and identified 10 PICOs with insufficient evidence to make a recommendation.
conclusionsThis clinical practice guideline provides evidence-based recommendations for the management of massively and non-massively bleeding critically ill adult patients and identifies areas where further research is needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.