Evidence map›Paper›PMID 34677488›Full record

ArticleMedicines (Basel, Switzerland)2021

COVID-19 Infection and Neuropathological Features.

Leonardo Freire-de-Lima, Aline Miranda Scovino, Leonardo Marques da Fonseca, Camilla Cristie Barreto Menezes, Carlos Antonio do Nascimento Santos, Marco Edilson Freire de Lima, Debora Decote-Ricardo, Matheus Freire-de-Lima, Kelli Monteiro da Costa, Jhenifer Santos Dos Reis and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicines (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Leonardo Freire-de-LimaInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.ORCID 0000-0003-3013-3173
Aline Miranda ScovinoInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.
Leonardo Marques da FonsecaInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.
Camilla Cristie Barreto MenezesInstituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, Brazil.
Carlos Antonio do Nascimento SantosInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.
Marco Edilson Freire de LimaDepartamento de Química Orgânica, Instituto de Química, Universidade Federal Rural do Rio de Janeiro, Rio de Janeiro 23890-000, Brazil.ORCID 0000-0003-0563-3483
Debora Decote-RicardoDepartamento de Microbiologia e Imunologia Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Rio de Janeiro 23890-000, Brazil.
Matheus Freire-de-LimaInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.
Kelli Monteiro da CostaInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.
Jhenifer Santos Dos ReisInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.
Marcos André Rodrigues da Costa SantosInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.
Celio Geraldo Freire-de-LimaInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.ORCID 0000-0002-4148-3657
Alexandre MorrotInstituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, Brazil.
Universidade Federal do Rio de Janeiro · BRUniversidade Federal Rural do Rio de Janeiro · BRFundação Oswaldo Cruz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathology associated with COVID-19 infection is progressively being revealed. Recent postmortem assessments have revealed acute airway inflammation as well as diffuse alveolar damage, which bears resemblance to severe acute respiratory syndromes induced by both SARS-CoV and MERS-CoV infections. Although recent papers have highlighted some neuropathologies associated with COVID-19 infection, little is known about this topic of great importance in the area of public health. Here, we discuss how neuroinflammation related to COVID-19 could be triggered by direct viral neuroinvasion and/or cytokine release over the course of the infection.

Indexed as

autoantibodiesCOVID-19 infectionneuroinflammationneuropathology

Identifiers

PMID34677488
PMCPMC8537119
OpenAlexW3206609385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.