Evidence map›Paper›PMID 34677461›Full record

ReviewMarine drugs2021

Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins.

Rawan Mackieh, Rita Abou-Nader, Rim Wehbe, César Mattei, Christian Legros, Ziad Fajloun, Jean Marc Sabatier

Open access · goldAbstract readReview
In one paragraph

Review in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. The Chemistry and Biology of the Tetrodotoxin Natural Product Family.Angewandte Chemie (International ed. in English) · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Molecular Mechanisms of Animal Toxins, Venoms and Antivenoms.International journal of molecular sciences · 2023
    Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Rawan MackiehFaculty of Sciences 3, Department of Biology, Lebanese University, Campus Michel Slayman Ras Maska, Tripoli 1352, Lebanon.
Rita Abou-NaderFaculty of Sciences 3, Department of Biology, Lebanese University, Campus Michel Slayman Ras Maska, Tripoli 1352, Lebanon.
Rim WehbeBiology Department, Faculty of Arts and Sciences, American University of Beirut, Beirut 1107 2020, Lebanon.
César MatteiUniversity of Angers, INSERM U1083, CNRS UMR 6015, MITOVASC, SFR ICAT, 49000 Angers, France.ORCID 0000-0002-2214-2611
Christian LegrosUniversity of Angers, INSERM U1083, CNRS UMR 6015, MITOVASC, SFR ICAT, 49000 Angers, France.ORCID 0000-0002-3346-7059
Ziad FajlounFaculty of Sciences 3, Department of Biology, Lebanese University, Campus Michel Slayman Ras Maska, Tripoli 1352, Lebanon.ORCID 0000-0002-6502-3110
Jean Marc SabatierThe Institute of NeuroPhysiopathology (INP), Aix-Marseille Université, CNRS, INP, 13385 Marseille, France.ORCID 0000-0002-9040-5647
Centre National de la Recherche Scientifique · FRLebanese University · LBAmerican University of Beirut · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Voltage-gated sodium channels (VGSCs) are considered to be one of the most important ion channels given their remarkable physiological role. VGSCs constitute a family of large transmembrane proteins that allow transmission, generation, and propagation of action potentials. This occurs by conducting Na

Indexed as

Biological ProductsAnalgesicsAnimalsHumansMarine ToxinsPainSea AnemonesShellfishSnailsTetraodontiformesVoltage-Gated Sodium ChannelsAnalgesicsBiological ProductsMarine ToxinsVoltage-Gated Sodium Channelscone snailmarine toxinsneurotoxinspufferfishsea anemoneshellfishVGSCs

Identifiers

PMID34677461
PMCPMC8537899
OpenAlexW3206896724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.