Evidence map›Paper›PMID 34677449›Full record

ArticleMarine drugs2021

Echinochrome A Protects against Ultraviolet B-induced Photoaging by Lowering Collagen Degradation and Inflammatory Cell Infiltration in Hairless Mice.

Jung Eun Seol, Sang Woo Ahn, Bomin Seol, Hyeong Rok Yun, Nammi Park, Hyoung Kyu Kim, Elena A Vasileva, Natalia P Mishchenko, Sergey A Fedoreyev, Valentin A Stonik and 1 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Protective and Reparative Effects ofJournal of microbiology and biotechnology · 2025
    Article
  3. Article
  4. Article
  5. Immune aging and infectious diseases.Chinese medical journal · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jung Eun SeolDepartment of Dermatology, Inje University Busan Paik Hospital, College of Medicine, Inje University, Busan 47392, Korea.
Sang Woo AhnDepartment of Dermatology, Inje University Busan Paik Hospital, College of Medicine, Inje University, Busan 47392, Korea.ORCID 0000-0003-4820-3870
Bomin SeolDepartment of Dermatology, Inje University Busan Paik Hospital, College of Medicine, Inje University, Busan 47392, Korea.
Hyeong Rok YunDepartment of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Smart Marine Therapeutic Center, Busan 47392, Korea.
Nammi ParkDepartment of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Smart Marine Therapeutic Center, Busan 47392, Korea.
Hyoung Kyu KimDepartment of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Smart Marine Therapeutic Center, Busan 47392, Korea.ORCID 0000-0002-1791-7865
Elena A VasilevaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.ORCID 0000-0001-7526-026X
Natalia P MishchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.ORCID 0000-0001-7616-574X
Sergey A FedoreyevG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.ORCID 0000-0002-4199-2099
Valentin A StonikG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.
Jin HanDepartment of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Smart Marine Therapeutic Center, Busan 47392, Korea.ORCID 0000-0003-1859-3425
Inje University · KRPacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences · RUInje University Busan Paik Hospital · KR

Funding

Inje University 2019 Inje University research grant
6 · The paper itself

Abstract

Echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone) has been known to exhibit anti-oxidative and anti-inflammatory effects. However, no study has been carried out on the efficacy of Ech A against skin photoaging; this process is largely mediated by oxidative stress. Six-week-old male SKH-1 hairless mice (

Indexed as

AnimalsAquatic OrganismsCollagenDisease Models, AnimalMaleMast CellsMiceMice, HairlessNaphthoquinonesProtective AgentsSkin AgingUltraviolet RaysWater Loss, InsensibleCollagenechinochrome ANaphthoquinonesProtective Agentsdermal collagen degenerationechinochrome Ahairless micemast cell infiltrationphotoaging

Identifiers

PMID34677449
PMCPMC8537837
OpenAlexW3202150855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.