ArticleMarine drugs2021
Efficacy of Chondroprotective Food Supplements Based on Collagen Hydrolysate and Compounds Isolated from Marine Organisms.
Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Bioactive Collagen Peptides in Veterinary and Biomedical Science-Part I: Molecular Identity, Gastrointestinal Bioavailability, and Receptor-Mediated Signaling, with Relevance to the Bile Acid Axis.Veterinary sciences · 2026Review
- Eggshell Membrane Peptides Alleviate IL-1β-Induced Inflammatory Responses and Extracellular Matrix Degradation in Canine Chondrocytes by Inhibiting the NF-κB Signaling Pathway.Animals : an open access journal from MDPI · 2026Article
- Nutraceuticals, Social Interaction, and Psychophysiological Influence on Pet Health and Well-Being: Focus on Dogs and Cats.Veterinary sciences · 2025Review
- Efficacy and Safety Assessment of a Dietary Supplement in a Rat Model of Osteoarthritis and Dogs with Arthritic Signs.Animals : an open access journal from MDPI · 2025Article
- Collagen Hydrolysates as Nutritional Support in Canine Osteoarthritis: A Narrative Review.Journal of animal physiology and animal nutrition · 2025Review
- Formulation and Characterization of Glucosamine Sulphate Potassium Chloride (GSPC) Loaded Emulgel for the Treatment of Osteoarthritis.Current rheumatology reviews · 2025Article
- Targeted Therapy of Antibody-Induced Autoimmune Arthritis Using Peptide-Guided Nanoparticles.International journal of molecular sciences · 2024Article
- Effect of Oral Administration of Collagen Peptide OG-5 on Advanced Atherosclerosis Development in ApoENutrients · 2024Article
- Non-surgical pain management for hip joint disease in veterinary medicine.Veterinarni medicina · 2024Review
- Research on Application of Japanese Quince (Nutrients · 2024Article
- Food-derived bioactive peptides potentiating therapeutic intervention in rheumatoid arthritis.Heliyon · 2024Review
- Article
- Marine Drug Discovery through Computer-Aided Approaches.Marine drugs · 2023Article
- Blood pH Analysis in Combination with Molecular Medical Tools in Relation to COVID-19 Symptoms.Biomedicines · 2023Article
- Delivery of bone morphogenetic protein-2 by crosslinking heparin to nile tilapia skin collagen for promotion of rat calvaria bone defect repair.Progress in biomaterials · 2023Article
- Molecular mechanisms and potential applications of chondroitin sulphate in managing post-traumatic osteoarthritis.Reumatologia · 2023Review
- Sustainable Applications of Animal Waste Proteins.Polymers · 2022Review
- Potential of Thermolysin-like Protease A69 in Preparation of Bovine Collagen Peptides with Moisture-Retention Ability and Antioxidative Activity.Marine drugs · 2021Article
- Evidence for Quantum Chemical Effects in Receptor-Ligand Binding Between Integrin and Collagen Fragments - A Computational Investigation With an Impact on Tissue Repair, Neurooncolgy and Glycobiology.Frontiers in molecular biosciences · 2021Article
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 4 countries.
Funding
Abstract
Osteoarthritis belongs to the most common joint diseases in humans and animals and shows increased incidence in older patients. The bioactivities of collagen hydrolysates, sulfated glucosamine and a special fatty acid enriched dog-food were tested in a dog patient study of 52 dogs as potential therapeutic treatment options in early osteoarthritis. Biophysical, biochemical, cell biological and molecular modeling methods support that these well-defined substances may act as effective nutraceuticals. Importantly, the applied collagen hydrolysates as well as sulfated glucosamine residues from marine organisms were strongly supported by both an animal model and molecular modeling of intermolecular interactions. Molecular modeling of predicted interaction dynamics was evaluated for the receptor proteins MMP-3 and ADAMTS-5. These proteins play a prominent role in the maintenance of cartilage health as well as innate and adapted immunity. Nutraceutical data were generated in a veterinary clinical study focusing on mobility and agility. Specifically, key clinical parameter (MMP-3 and TIMP-1) were obtained from blood probes of German shepherd dogs with early osteoarthritis symptoms fed with collagen hydrolysates. Collagen hydrolysate, a chondroprotective food supplement was examined by high resolution NMR experiments. Molecular modeling simulations were used to further characterize the interaction potency of collagen fragments and glucosamines with protein receptor structures. Potential beneficial effects of collagen hydrolysates, sulfated glycans (i.e., sulfated glucosamine from crabs and mussels) and lipids, especially, eicosapentaenoic acid (extracted from fish oil) on biochemical and physiological processes are discussed here in the context of human and veterinary medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.