Evidence map›Paper›PMID 34677380›Full record

ArticleMetabolites2021

Knockout of the Amino Acid Transporter SLC6A19 and Autoimmune Diabetes Incidence in Female Non-Obese Diabetic (NOD) Mice.

Matthew F Waters, Viviane Delghingaro-Augusto, Kiran Javed, Jane E Dahlstrom, Gaetan Burgio, Stefan Bröer, Christopher J Nolan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Matthew F WatersAustralian National University Medical School, Australian National University, Acton, ACT 2601, Australia.ORCID 0000-0001-7334-9295
Viviane Delghingaro-AugustoAustralian National University Medical School, Australian National University, Acton, ACT 2601, Australia.ORCID 0000-0002-5107-2384
Kiran JavedResearch School of Biology, Australian National University, Acton, ACT 2601, Australia.
Jane E DahlstromAustralian National University Medical School, Australian National University, Acton, ACT 2601, Australia.ORCID 0000-0001-5608-693X
Gaetan BurgioJohn Curtin School of Medical Research, Australian National University, Acton, ACT 2601, Australia.ORCID 0000-0002-7434-926X
Stefan BröerResearch School of Biology, Australian National University, Acton, ACT 2601, Australia.ORCID 0000-0002-8040-1634
Christopher J NolanAustralian National University Medical School, Australian National University, Acton, ACT 2601, Australia.ORCID 0000-0002-6964-3819
Australian National University · AU

Funding

National Health and Medical Research Council APP1128442
6 · The paper itself

Abstract

High protein feeding has been shown to accelerate the development of type 1 diabetes in female non-obese diabetic (NOD) mice. Here, we investigated whether reducing systemic amino acid availability via knockout of the

Indexed as

amino acidaminoaciduriadiabetes incidenceinsulitisneutral amino acid transporternon-obese diabetic mousepancreatic isletSlc6a19 deficiencytype 1 diabetes

Identifiers

PMID34677380
PMCPMC8540324
OpenAlexW3202829479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.