ArticleBiosensors2021
Smartphone-Based Chemiluminescent Origami µPAD for the Rapid Assessment of Glucose Blood Levels.
Article in Biosensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- Monolayer graphene/platinum-modified 3D origami microfluidic paper-based biosensor for smartphone-assisted biomarkers detection.ADMET & DMPK · 2025Article
- Microfluidic-based systems for the management of diabetes.Drug delivery and translational research · 2024Review
- Optical Image Sensors for Smart Analytical Chemiluminescence Biosensors.Bioengineering (Basel, Switzerland) · 2024Review
- Smartphone-Based Chemiluminescence Glucose Biosensor Employing a Peroxidase-Mimicking, Guanosine-Based Self-Assembled Hydrogel.Biosensors · 2023Article
- Enzyme-Based Biosensors and Their Applications.Biosensors · 2023Article
- REASSURED diagnostics at point-of-care in sub-Saharan Africa: A scoping review.PLOS global public health · 2023Article
- Dual-signal readout paper-based wearable biosensor with a 3D origami structure for multiplexed analyte detection in sweat.Microsystems & nanoengineering · 2023Article
- An Origami Paper-Based Biosensor for Allergen Detection by Chemiluminescence Immunoassay on Magnetic Microbeads.Biosensors · 2022Article
- A Butyrylcholinesterase Camera Biosensor Tested for Carbofuran and Paraoxon Assay.International journal of analytical chemistry · 2022Article
- Microfluidic Paper-based Device for Medicinal Diagnosis.Current topics in medicinal chemistry · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Microfluidic paper analytical devices (µPADs) represent one of the most appealing trends in the development of simple and inexpensive analytical systems for diagnostic applications at the point of care (POC). Herein, we describe a smartphone-based origami µPAD for the quantitative determination of glucose in blood samples based on the glucose oxidase-catalyzed oxidation of glucose leading to hydrogen peroxide, which is then detected by means of the luminol/hexacyanoferrate(III) chemiluminescent (CL) system. By exploiting the foldable µPAD format, a two-step analytical procedure has been implemented. First, the diluted blood sample was added, and hydrogen peroxide was accumulated, then the biosensor was folded, and a transport buffer was added to bring hydrogen peroxide in contact with CL reagents, thus promoting the CL reaction. To enable POC applicability, the reagents required for the assay were preloaded in the µPAD so that no chemicals handling was required, and a 3D-printed portable device was developed for measuring the CL emission using the smartphone's CMOS camera. The µPAD was stable for 30-day storage at room temperature and the assay, displaying a limit of detection of 10 µmol L
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.