Evidence map›Paper›PMID 34677301›Full record

ArticleJournal of imaging2021

A Combined Radiomics and Machine Learning Approach to Distinguish Clinically Significant Prostate Lesions on a Publicly Available MRI Dataset.

Leandro Donisi, Giuseppe Cesarelli, Anna Castaldo, Davide Raffaele De Lucia, Francesca Nessuno, Gaia Spadarella, Carlo Ricciardi

Abstract read
In one paragraph

Article in Journal of imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Prostate Cancer Classification Using Quantum Machine Learning on Multi-parametric MRI.Proceedings of SPIE--the International Society for Optical Engineering · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leandro DonisiDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-9746-2265
Giuseppe CesarelliBioengineering Unit, Institute of Care and Scientific Research Maugeri, 27100 Pavia, Italy.ORCID 0000-0001-8303-5900
Anna CastaldoDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
Davide Raffaele De LuciaDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-5059-4615
Francesca NessunoDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
Gaia SpadarellaDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
Carlo RicciardiBioengineering Unit, Institute of Care and Scientific Research Maugeri, 27100 Pavia, Italy.ORCID 0000-0001-7290-6432

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although prostate cancer is one of the most common causes of mortality and morbidity in advancing-age males, early diagnosis improves prognosis and modifies the therapy of choice. The aim of this study was the evaluation of a combined radiomics and machine learning approach on a publicly available dataset in order to distinguish a clinically significant from a clinically non-significant prostate lesion. A total of 299 prostate lesions were included in the analysis. A univariate statistical analysis was performed to prove the goodness of the 60 extracted radiomic features in distinguishing prostate lesions. Then, a 10-fold cross-validation was used to train and test some models and the evaluation metrics were calculated; finally, a hold-out was performed and a wrapper feature selection was applied. The employed algorithms were Naïve bayes, K nearest neighbour and some tree-based ones. The tree-based algorithms achieved the highest evaluation metrics, with accuracies over 80%, and area-under-the-curve receiver-operating characteristics below 0.80. Combined machine learning algorithms and radiomics based on clinical, routine, multiparametric, magnetic-resonance imaging were demonstrated to be a useful tool in prostate cancer stratification.

Indexed as

machine learningMRIprostate cancerradiomics

Identifiers

PMID34677301
PMCPMC8540196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.