ReviewCurrent oncology (Toronto, Ont.)2021
CRAFT-A Proposed Framework for Decentralized Clinical Trials Participation in Canada.
Review in Current oncology (Toronto, Ont.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Impact of precision oncology research in pediatric poor prognosis cancer: patient, parent and healthcare provider perspectives.BMC cancer · 2026Article
- Capacity building at an Australian regional clinical trials unit: determinants of growth and correlation with a capability framework.BMC medical research methodology · 2026Article
- Implementing a national clinical trial navigator program: a qualitative CFIR analysis of barriers and facilitators from the perspective of people with lived cancer experience.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- A New Dawn-Using Teletrials for Early Phase Drug Development: A Practical Guideline.Asia-Pacific journal of clinical oncology · 2026Review
- Bridging the rural cancer gap: why clinical trials must include rural patients.Cancer causes & control : CCC · 2025Article
- Integrating mHealth Innovations into Decentralized Oncology Trials.Journal of medical systems · 2025Review
- Decentralized subject recruitment for a prospective community surveillance system: The influence of social determinants of health on inclusion of minorities in research.Journal of clinical and translational science · 2025Article
- The status quo of the development of decentralized clinical trials.Frontiers in medicine · 2025Review
- Qualitative Study of Health Care Professional Perspectives on Recruiting Minority Patients in Cancer Trials.Health equity · 2025Article
- Screening log: Challenges in community patient recruitment for gynecologic oncology clinical trials.Contemporary clinical trials communications · 2024Article
- Facilitation of Enrollment onto Cancer Clinical Trials Using a Novel Navigator-Assisted Program: A Cross-Sectional Study.Current oncology (Toronto, Ont.) · 2024Article
- What motivates people with type 2 diabetes mellitus to participate in clinical trials from home?Clinical and translational science · 2024Article
- Exploring Demographic Representation and Reporting in Lung Cancer Clinical Trials with Canadian Sites from 2013 to 2023.Current oncology (Toronto, Ont.) · 2024Review
- Patient and Public Perceptions in Canada About Decentralized and Hybrid Clinical Trials: "It's About Time we Bring Trials to People".Therapeutic innovation & regulatory science · 2024Article
- Effect of distance to tertiary centre on enrolment of paediatric patients with relapsed or refractory cancer on early phase clinical trials in British Columbia.Paediatrics & child health · 2024Article
- Evaluation of the Geographical Accessibility of Genome-Matched Clinical Trials on a National Experience.The oncologist · 2024Article
- Access to innovative therapies in pediatric oncology: Report of the nationwide experience in Canada.Cancer medicine · 2024Article
- Key Considerations for the Treatment of Advanced Breast Cancer in Older Adults: An Expert Consensus of the Canadian Treatment Landscape.Current oncology (Toronto, Ont.) · 2023Review
- Current Challenges and Disparities in the Delivery of Equitable Breast Cancer Care in Canada.Current oncology (Toronto, Ont.) · 2023Review
- A capability framework to inform the fundamental requirements for clinical trial unit development, growth and long term success in outer metropolitan and rural areas.Contemporary clinical trials communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canada's vast geography, and centralized delivery of cancer care and clinical trials create barriers for trial participation for patients in remote and rural settings. The development and implementation of a framework that enables safe and regulatory compliant trial participation through local healthcare providers would benefit Canadian patients, clinicians, trial sponsors and the health care system. To address this issue, representatives of Canada's cancer clinical trial community met to identify key challenges and develop recommendations for remote patient participation in trials. A structured literature review identified remote/rural trial delivery models. A panel of expert stakeholders reviewed the models and participated in a workshop to assess health system readiness, identify needed processes, tools and mechanisms, and develop recommendations for a Canadian framework for decentralized clinical trial conduct. The Canadian Remote Access Framework for clinical Trials (CRAFT) represents a risk-based approach used by site investigators to delegate responsibilities for a given trial to satellite health centres within a hub-and-spoke "trial cluster". The Framework includes specific recommendations to ensure research experience, capacity, regulatory compliance and patient safety. Canada's cancer care and telemedicine systems can be leveraged to enable broader access to clinical trials for patients who are geographically remote from cancer centres. CRAFT's risk-based framework is based on other successful models of remote trial patient management and is in the pilot implementation phase in Canada.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.