Evidence map›Paper›PMID 34677197›Full record

ReviewJournal of cardiovascular development and disease2021

Acute and Chronic Effects of COVID-19 on the Cardiovascular System.

Victor Arévalos, Luis Ortega-Paz, Juan José Rodríguez-Arias, Margarita Calvo López, Leticia Castrillo-Golvano, Anthony Salazar-Rodríguez, Marta Sabaté-Tormos, Francesco Spione, Manel Sabaté, Salvatore Brugaletta

Abstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Coronary Implications of COVID-19.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025
    Review
  5. Observational
  6. Cardiorespiratory optimal point in post-COVID-19 patients: a cross-sectional study.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Victor ArévalosDepartment of Cardiology, Clinic Cardiovascular Institute, Hospital Clinic, 08036 Barcelona, Spain.ORCID 0000-0001-9525-1133
Luis Ortega-PazDepartment of Cardiology, Clinic Cardiovascular Institute, Hospital Clinic, 08036 Barcelona, Spain.ORCID 0000-0002-9567-3253
Juan José Rodríguez-AriasDepartment of Cardiology, Clinic Cardiovascular Institute, Hospital Clinic, 08036 Barcelona, Spain.
Margarita Calvo LópezDepartment of Cardiology, Clinic Cardiovascular Institute, Hospital Clinic, 08036 Barcelona, Spain.
Leticia Castrillo-GolvanoDepartment of Cardiology, Clinic Cardiovascular Institute, Hospital Clinic, 08036 Barcelona, Spain.
Anthony Salazar-RodríguezDepartment of Cardiology, Clinic Cardiovascular Institute, Hospital Clinic, 08036 Barcelona, Spain.
Marta Sabaté-TormosDepartment of Medicine, Medical School, Universitat de Barcelona, 08036 Barcelona, Spain.
Francesco SpioneDepartment of Cardiology, Clinic Cardiovascular Institute, Hospital Clinic, 08036 Barcelona, Spain.
Manel SabatéDepartment of Cardiology, Clinic Cardiovascular Institute, Hospital Clinic, 08036 Barcelona, Spain.ORCID 0000-0002-2316-3705
Salvatore BrugalettaDepartment of Cardiology, Clinic Cardiovascular Institute, Hospital Clinic, 08036 Barcelona, Spain.ORCID 0000-0001-5845-1435

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 has shown significant morbidity with the involvement of multiple systems, including the cardiovascular system. Cardiovascular manifestations in the acute phase can include myocardial injury itself, myocardial infarction, venous thromboembolic events, myocarditis, Takotsubo syndrome, and different arrhythmic events. Myocardial injury defined by the rise of cardiac biomarkers in blood has been found in multiple studies with a prevalence of about 20%. Its presence is related to worse clinical outcomes and in-hospital mortality. The mechanisms of myocardial injury have been the subject of intense research but still need to be clarified. The characterization of the cardiac affectation with echocardiography and cardiac magnetic resonance has found mixed results in different studies, with a striking incidence of imaging criteria for myocarditis. Regarding post-acute and chronic follow-up results, the persistence of symptoms and imaging changes in recovered COVID-19 patients has raised concerns about the duration and the possible significance of these findings. Even though the knowledge about this disease has increased incredibly in the last year, many aspects are still unclear and warrant further research.

Indexed as

coronavirus disease 2019long-term outcomemyocardial infarctionmyocardial injurymyocarditispulmonary embolismSARS-CoV-2

Identifiers

PMID34677197
PMCPMC8541609

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.