ArticleeLife2021
Molecular reconstruction of recurrent evolutionary switching in olfactory receptor specificity.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Transcriptomic Analysis and Comparative Analysis of Gene Families Related to Environmental Adaptation in Two Grylloblattodea Species:Ecology and evolution · 2025Article
- Alternative strategies based on transgenic Drosophila melanogaster for the functional characterization of insect Ionotropic Receptors.Biological research · 2025Article
- Comparative single-cell transcriptomic atlases of drosophilid brains suggest glial evolution during ecological adaptation.PLoS biology · 2025Article
- Functional characterization and evolution of olfactory responses in coeloconic sensilla of the global fruit pest Drosophila suzukii.BMC biology · 2025Article
- Attraction and aversion of noctuid moths to fermented food sources coordinated by olfactory receptors from distinct gene families.BMC biology · 2025Article
- Olfactory sensory neuron population expansions influence projection neuron adaptation and enhance odour tracking.Nature communications · 2024Article
- Chemogenetic activation of mammalian brain neurons expressing insect Ionotropic Receptors by systemic ligand precursor administration.Communications biology · 2024Article
- Article
- Odor-regulated oviposition behavior in an ecological specialist.Nature communications · 2023Article
- A tale of two copies: Evolutionary trajectories of moth pheromone receptors.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Article
- The human odorant receptor OR10A6 is tuned to the pheromone of the commensal fruit flyiScience · 2022Article
- Temperature-dependent genetics of thermotolerance between yeast species.Frontiers in ecology and evolution · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Olfactory receptor repertoires exhibit remarkable functional diversity, but how these proteins have evolved is poorly understood. Through analysis of extant and ancestrally reconstructed drosophilid olfactory receptors from the Ionotropic receptor (Ir) family, we investigated evolution of two organic acid-sensing receptors, Ir75a and Ir75b. Despite their low amino acid identity, we identify a common 'hotspot' in their ligand-binding pocket that has a major effect on changing the specificity of both Irs, as well as at least two distinct functional transitions in Ir75a during evolution. Moreover, we show that odor specificity is refined by changes in additional, receptor-specific sites, including those outside the ligand-binding pocket. Our work reveals how a core, common determinant of ligand-tuning acts within epistatic and allosteric networks of substitutions to lead to functional evolution of olfactory receptors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.