Evidence map›Paper›PMID 34677084›Full record

ArticlePhysiological genomics2021

Platelet proteome dynamics in hibernating 13-lined ground squirrels.

Scott Cooper, Phillip A Wilmarth, Jennifer M Cunliffe, John Klimek, Jiaqing Pang, Samuel Tassi Yunga, Jessica Minnier, Ashok Reddy, Larry David, Joseph E Aslan

Open access · greenAbstract readComparative Study
In one paragraph

Article in Physiological genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Hibernation and hemostasis.Frontiers in physiology · 2023
    Review
  6. Platelets from 13-lined ground squirrels are resistant to cold storage lesions.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Scott CooperBiology Department, University of Wisconsin-La Crosse, La Crosse, Wisconsin.ORCID 0000-0002-2555-6457
Phillip A WilmarthProteomics Shared Resource, Oregon Health & Science University, Portland, Oregon.
Jennifer M CunliffeProteomics Shared Resource, Oregon Health & Science University, Portland, Oregon.
John KlimekProteomics Shared Resource, Oregon Health & Science University, Portland, Oregon.
Jiaqing PangDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon.
Samuel Tassi YungaCancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, Oregon.
Jessica MinnierDivision of Cardiology, Department of Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon.
Ashok ReddyProteomics Shared Resource, Oregon Health & Science University, Portland, Oregon.
Larry DavidProteomics Shared Resource, Oregon Health & Science University, Portland, Oregon.
Joseph E AslanDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon.ORCID 0000-0002-8873-0387
Oregon Health & Science University · USUniversity of Wisconsin–La Crosse · US

Funding

Understanding the origins of rapid recurrence of pancreatic cancer after resectionP30CA069533 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Luiz Eduardo Bertassoni · 1997 to 2026
$60.5M
Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TED S ACOTT · 1995 to 2026
$19.4M
Pathway Maps of Platelet Phenotype and FunctionR01HL146549 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ASLAN, JOSEPH E · 2019 to 2023
$2.5M
Mechanism of cold storage lesion resistance in hibernating ground squirrel platelets.R15HL093680 · NHLBI · UNIVERSITY OF WISCONSIN LA CROSSE · PI COOPER, SCOTT T · 2008 to 2023
$1.2M
LTQ Orbitrap VelosS10OD012246 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAVID, LARRY L · 2012 to 2012
$854k
NCI NIH HHS P30 CA069533NEI NIH HHS P30 EY010572NHLBI NIH HHS R01 HL146549NHLBI NIH HHS R15 HL093680NIH HHS S10 OD012246
6 · The paper itself

Abstract

Hibernating mammals undergo a dramatic drop in temperature and blood flow during torpor, yet avoid stasis blood clotting through mechanisms that remain unspecified. The effects of hibernation on hemostasis are especially complex, as cold temperatures generally activate platelets, resulting in platelet clearance and cold storage lesions in the context of blood transfusion. With a hibernating body temperature of 4°C-8°C, 13-lined ground squirrels (

Indexed as

SeasonsAnimalsBlood PlateletsChromatography, LiquidFemaleHibernationHumansMaleProteomeProteomicsSciuridaeSpecies SpecificityTandem Mass SpectrometryTemperatureProteomehypothermialipoproteinplatelet storageproteomicstransfusion

Identifiers

PMID34677084
PMCPMC8616595
OpenAlexW3207668034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.