Evidence map›Paper›PMID 34676988›Full record

ArticlePharmacology research & perspectives2021

Chemogenetic stimulation of the G

Jae-Hong Kim, Md Habibur Rahman, Won Ha Lee, Kyoungho Suk

Open access · goldAbstract read
In one paragraph

Article in Pharmacology research & perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

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  18. Chemogenetic stimulation of the GPharmacology research & perspectives · 2021
    Article
  19. Glial pharmacology in Asia & Beyond.Pharmacology research & perspectives · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jae-Hong KimDepartment of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Md Habibur RahmanDepartment of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Won Ha LeeSchool of Life Sciences, Brain Korea 21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Republic of Korea.
Kyoungho SukDepartment of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.ORCID 0000-0002-9555-4203
Kyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engineered G protein-coupled receptors (GPCRs) are commonly used in chemogenetics as designer receptors exclusively activated by designer drugs (DREADDs). Although several GPCRs have been studied in astrocytes using a chemogenetic approach, the functional role of the astrocytic G

Indexed as

AnimalsAstrocytesBrainClozapineCognitive DysfunctionCytokinesDesigner DrugsDisease Models, AnimalGTP-Binding Protein alpha Subunits, Gi-GoHippocampusLipopolysaccharidesMaleMiceMice, Inbred C57BLMolecular Targeted TherapyNeuroinflammatory DiseasesClozapineclozapine N-oxideCytokinesDesigner DrugsGTP-Binding Protein alpha Subunits, Gi-GoLipopolysaccharidesNitric OxideNitric Oxide Synthase Type IINos2 protein, mouseReceptors, G-Protein-CoupledastrocytechemogeneticsGi-DREADDhM4Dineuroinflammation

Identifiers

PMID34676988
PMCPMC8532135
OpenAlexW3206051478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.