ArticleChemistry (Weinheim an der Bergstrasse, Germany)2022
Catalytic Atroposelective C7 Functionalisation of Indolines and Indoles.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Atroposelective catalysis.Nature reviews. Chemistry · 2024Review
- Organocatalytic intramolecular (4 + 2) annulation of enals with ynamides: atroposelective synthesis of axially chiral 7-aryl indolines.Chemical science · 2023Article
- The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation.Journal of medicinal chemistry · 2022Article
- Catalytic Atroposelective C7 Functionalisation of Indolines and Indoles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
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3 authors.
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Abstract
Axially chiral atropisomeric compounds are widely applied in asymmetric catalysis and medicinal chemistry. In particular, axially chiral indole- and indoline-based frameworks have been recognised as important heterobiaryl classes because they are the core units of bioactive natural alkaloids, chiral ligands and bioactive compounds. Among them, the synthesis of C7-substituted indole biaryls and the analogous indoline derivatives is particularly challenging, and methods for their efficient synthesis are in high demand. Transition-metal catalysis is considered one of the most efficient methods to construct atropisomers. Here, we report the enantioselective synthesis of C7-indolino- and C7-indolo biaryl atropisomers by means of C-H functionalisation catalysed by chiral RhJasCp complexes.
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