Evidence map›Paper›PMID 34676855›Full record

ArticleChemical communications (Cambridge, England)2021

Gustavo Perez Ortiz, John D Sidda, Emmanuel L C de Los Santos, Catherine B Hubert, Sarah M Barry

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gustavo Perez OrtizDepartment of Chemistry, Faculty of Natural, Mathematical & Engineering Sciences, Britannia House, 7 Trinity St, London, SE1 1DB, UK. sarah.barry@kcl.ac.uk.
John D SiddaDepartment of Chemistry, Faculty of Natural, Mathematical & Engineering Sciences, Britannia House, 7 Trinity St, London, SE1 1DB, UK. sarah.barry@kcl.ac.uk.
Emmanuel L C de Los SantosSchool of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.ORCID http://orcid.org/0000-0002-9496-9407
Catherine B HubertDepartment of Chemistry, Faculty of Natural, Mathematical & Engineering Sciences, Britannia House, 7 Trinity St, London, SE1 1DB, UK. sarah.barry@kcl.ac.uk.ORCID http://orcid.org/0000-0001-6057-8734
Sarah M BarryDepartment of Chemistry, Faculty of Natural, Mathematical & Engineering Sciences, Britannia House, 7 Trinity St, London, SE1 1DB, UK. sarah.barry@kcl.ac.uk.ORCID http://orcid.org/0000-0001-8188-2153

Funding

Biotechnology and Biological Sciences Research Council BB/M017982/1Medical Research Council MC_PC_14105Wellcome Trust
6 · The paper itself

Abstract

The antimycobacterial peptides, rufomycins, have their antibiotic activity conferred by oxidative tailoring of the cyclic peptide. Here we elucidate the roles of cytochrome P450s RufS and RufM in regioselective epoxidation and alkyl oxidation respectively and demonstrate how RufM and RufS create a complex product profile dependent on redox partner availability. Finally, we report the

Indexed as

Amino Acid SequenceAntitubercular AgentsBacterial ProteinsCytochrome P-450 Enzyme SystemOxidation-ReductionPeptides, CyclicStreptomycesAntitubercular AgentsBacterial ProteinsCytochrome P-450 Enzyme SystemPeptides, Cyclic

Identifiers

PMID34676855
PMCPMC8577248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.