ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2021
Rapid, dose-dependent and efficient inactivation of surface dried SARS-CoV-2 by 254 nm UV-C irradiation.
Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Novel treatment of infectious keratitis in canine corneas using ultraviolet C (UV-C) light.Veterinary ophthalmology · 2025Article
- Evaluation of the killing effects of UVFrontiers in veterinary science · 2025Article
- Article
- Estimation of the UV susceptibility of aerosolized SARS-CoV-2 to 254 nm irradiation using CFD-based room disinfection simulations.Scientific reports · 2024Article
- Impacts of Surface Characteristics and Dew Point on the Blue-Light (BLMicroorganisms · 2023Article
- Virus Behavior after UVMicroorganisms · 2023Article
- Inactivation characteristics of a 280 nm Deep-UV irradiation dose on aerosolized SARS-CoV-2.Environment international · 2023Article
- Solar desalination/purification (solar stills, humidification-dehumidification, solar disinfection) in high altitude during COVID19: Insights of gastrointestinal manifestations and systems' mechanism.Journal of hazardous materials advances · 2023Article
- Towards Effective, Sustainable Solution for Hospital Wastewater Treatment to Cope with the Post-Pandemic Era.International journal of environmental research and public health · 2023Review
- Impact of needle-point bipolar ionization system in the reduction of bioaerosols in collective transport.The Science of the total environment · 2023Article
- Quantitative determination of the electron beam radiation dose for SARS-CoV-2 inactivation to decontaminate frozen food packaging.Virologica Sinica · 2022Article
- UV-C Light Completely Blocks Aerosol Transmission of Highly Contagious SARS-CoV-2 Variants WA1 and Delta in Hamsters.Environmental science & technology · 2022Article
- Review
- Inactivation of aerosolized SARS-CoV-2 by 254 nm UV-C irradiation.Indoor air · 2022Article
- Rapid SARS-CoV-2 disinfection on distant surfaces with UV-C: The inactivation is affected by the type of material.Journal of photochemistry and photobiology · 2022Article
- Effective ultraviolet C light disinfection of respirators demonstrated in challenges with Geobacillus stearothermophilus spores and SARS-CoV-2 virus.The Journal of hospital infection · 2022Article
- UV-C light completely blocks highly contagious Delta SARS-CoV-2 aerosol transmission in hamsters.bioRxiv : the preprint server for biology · 2022Article
- UVC, UVB and UVA susceptibility of Phi6 and its suitability as a SARS-CoV-2 surrogate.AIMS microbiology · 2022Article
- Article
- UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication.Scientific reports · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe COVID-19 pandemic urges for cheap, reliable, and rapid technologies for disinfection and decontamination. One frequently proposed method is ultraviolet (UV)-C irradiation. UV-C doses necessary to achieve inactivation of high-titre SARS-CoV-2 are poorly defined.
aimWe investigated whether short exposure of SARS-CoV-2 to UV-C irradiation sufficiently reduces viral infectivity and doses necessary to achieve an at least 6-log reduction in viral titres.
methodsUsing a box and two handheld systems designed to decontaminate objects and surfaces, we evaluated the efficacy of 254 nm UV-C treatment to inactivate surface dried high-titre SARS-CoV-2.
resultsDrying for 2 hours did not have a major impact on the infectivity of SARS-CoV-2, indicating that exhaled virus in droplets or aerosols stays infectious on surfaces for at least a certain amount of time. Short exposure of high titre surface dried virus (3-5*10^6 IU/ml) with UV-C light (16 mJ/cm2) resulted in a total inactivation of SARS-CoV-2. Dose-dependency experiments revealed that 3.5 mJ/cm2 were still effective to achieve a > 6-log reduction in viral titres, whereas 1.75 mJ/cm2 lowered infectivity only by one order of magnitude.
conclusionsSARS-CoV-2 is rapidly inactivated by relatively low doses of UV-C irradiation and the relationship between UV-C dose and log-viral titre reduction of surface residing SARS-CoV-2 is nonlinear. Our findings emphasize that it is necessary to assure sufficient and complete exposure of all relevant areas by integrated UV-C doses of at least 3.5 mJ/cm2 at 254 nm. Altogether, UV-C treatment is an effective non-chemical option to decontaminate surfaces from high-titre infectious SARS-CoV-2.
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