Observational studyAmerican journal of physiology. Heart and circulatory physiology2021
Blood volume expansion, normovolemia, and clinical outcomes in chronic human heart failure: more is better.
Observational study in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Association of polycythemia with outcomes of acute decompensated heart failure: A matched and weighted cohort analysis.PloS one · 2026Article
- Anti-inflammatory interventions in coronary artery disease: antipodal responses requiring targeted therapeutic strategies.Basic research in cardiology · 2025Review
- Venous Hematocrit: Caveats to Informing Blood Volume and Relative Risk in Chronic Heart Failure.Journal of the American Heart Association · 2025Article
- Understanding the variability in red cell and plasma volume combinations can help guide management in heart failure.ESC heart failure · 2025Article
- Congestion/decongestion in heart failure: what does it mean, how do we assess it, and what are we missing?-is there utility in measuring volume?Heart failure reviews · 2024Review
- Relationship between BUN/Cr and Prognosis of HF Across the Full Spectrum of Ejection Fraction.Arquivos brasileiros de cardiologia · 2023Article
- Measurement of Blood Volume in Patients with Heart Failure: Clinical Relevance, Surrogates, Historical Background and Contemporary Methodology.Heart international · 2023Review
- Clinically unrecognized plasma volume expansion predicts long-term all-cause-mortality in chronic heart failure.Clinical cardiology · 2022Article
- Fluid Volume Homeostasis in Heart Failure: A Tale of 2 Circulations.Journal of the American Heart Association · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expansion in blood volume (BV) is a well-recognized response to arterial underfilling secondary to impaired cardiac output in heart failure (HF). However, the effectiveness of this response in terms of outcomes remains inadequately understood. Prospective analysis was undertaken in 110 patients with HF hospitalized and treated for fluid overload. BVs were measured in a compensated state at the hospital discharge using the indicator-dilution methodology. Data were analyzed for composite 1-year HF-related mortality/first rehospitalization. Despite uniform standard of care, marked heterogeneity in BVs was identified across the cohort. The cohort was stratified by BV expansion greater than or equal to +25% above normal (51% of cohort), mild-moderate expansion (22%), and normal BV (27%). Kaplan-Meier (K-M) survival estimates and regression analyses revealed BV expansion (greater than or equal to +25%) to be associated with better event-free survival relative to normal BV (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.