Evidence map›Paper›PMID 34676697›Full record

ArticleHepatology communications2022

Frailty and the Risk of Acute Kidney Injury Among Patients With Cirrhosis.

Giuseppe Cullaro, Elizabeth C Verna, Andres Duarte-Rojo, Matthew R Kappus, Daniel R Ganger, Robert S Rahimi, Brian Boyarsky, Dorry L Segev, Mara McAdams-DeMarco, Daniela P Ladner and 3 more

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
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  9. Review
  10. Observational
  11. Article
  12. Review
  13. Article
  14. Article
  15. Managing a Prospective Liver Transplant Recipient on the Waiting List.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Giuseppe CullaroDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2935-0245
Elizabeth C VernaCenter for Liver Disease and Transplantation, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Andres Duarte-RojoCenter for Liver Diseases, Thomas A. Starzl Transplantation Institute, and Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-5377-9295
Matthew R KappusDivision of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-3365-5903
Daniel R GangerDivision of Gastroenterology and Hepatology, Department of Medicine, Northwestern Medicine, Chicago, IL, USA.
Robert S RahimiAnnette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Baylor Scott and White, Dallas, TX, USA.ORCID 0000-0002-2595-1852
Brian BoyarskyDepartment of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Dorry L SegevDepartment of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Mara McAdams-DeMarcoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Daniela P LadnerDivision of Transplantation, Department of Surgery, Northwestern Medicine, Chicago, IL, USA.
Michael L VolkDivision of Gastroenterology & Hepatology, and Transplantation Institute, Loma Linda University Health, Loma Linda, CA, USA.
Chi-Yuan HsuDivision of Nephrology, Department of Medicine, University of California, San Francisco, CA, USA.
Jennifer C LaiDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2092-6380
Johns Hopkins University · USUniversity of California, San Francisco · USBaylor University Medical Center · USColumbia University · USDuke University · USLoma Linda University Medical Center · USNorthwestern Medicine · USNorthwestern University · USUniversity of Pittsburgh Medical Center · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bruce Mao Zheng Wang · 1986 to 2026
$30.7M
The spectrum of cognitive impairment including Alzheimer’s Disease and Related Dementias after liver transplantationR01AG059183 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2018 to 2026
$9.9M
Patient Oriented Research in Kidney DiseaseK24DK092291 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN · 2011 to 2020
$1.2M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Frailty and Functional Status in Older Liver Transplant PatientsK23AG048337 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAI, JENNIFER C. · 2014 to 2018
$911k
Application of Novel Biomarkers of Renal Health in Cirrhosis Patients to Stratify Risk of Acute Kidney Injury Occurrence and ReversibilityK23DK131278 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Giuseppe Cullaro · 2022 to 2026
$812k
Aggressive Organ Procurement Organization Report Cards to Safely Increase Kidney TransplantationF32DK124941 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BOYARSKY, BRIAN · 2020 to 2020
$81k
NIA NIH HHS K23 AG048337NIA NIH HHS R01 AG059183NIDDK NIH HHS F32 DK124941NIDDK NIH HHS K23 DK131278NIDDK NIH HHS K24 DK092291NIDDK NIH HHS K24 DK101828NIDDK NIH HHS L30 DK133959NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

Acute kidney injury (AKI) and frailty are major drivers of outcomes among patients with cirrhosis. What is unknown is the impact of physical frailty on the development of AKI. We included adults with cirrhosis without hepatocellular carcinoma listed for liver transplantation at nine US centers (n = 1,033). Frailty was assessed using the Liver Frailty Index (LFI); "frail" was defined by LFI ≥ 4.2. Chronic kidney disease as a baseline estimated glomerular filtration rate <60 mL/min/1.73 m

Indexed as

Acute Kidney InjuryFrailtyHumansLiver CirrhosisProspective StudiesWaiting Lists

Identifiers

PMID34676697
PMCPMC8948591
OpenAlexW3207515343

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.