Evidence map›Paper›PMID 34676625›Full record

ArticleHuman brain mapping2022

A parallel attention-augmented bilinear network for early magnetic resonance imaging-based diagnosis of Alzheimer's disease.

Hao Guan, Chaoyue Wang, Jian Cheng, Jing Jing, Tao Liu

Abstract read
In one paragraph

Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hao GuanSchool of Computer Science, Faculty of Engineering, The University of Sydney, Darlington, New South Wales, Australia.
Chaoyue WangSchool of Computer Science, Faculty of Engineering, The University of Sydney, Darlington, New South Wales, Australia.
Jian ChengBeijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, China.
Jing JingChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Tao LiuBeijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, China.ORCID 0000-0002-7783-3073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Structural magnetic resonance imaging (sMRI) can capture the spatial patterns of brain atrophy in Alzheimer's disease (AD) and incipient dementia. Recently, many sMRI-based deep learning methods have been developed for AD diagnosis. Some of these methods utilize neural networks to extract high-level representations on the basis of handcrafted features, while others attempt to learn useful features from brain regions proposed by a separate module. However, these methods require considerable manual engineering. Their stepwise training procedures would introduce cascading errors. Here, we propose the parallel attention-augmented bilinear network, a novel deep learning framework for AD diagnosis. Based on a 3D convolutional neural network, the framework directly learns both global and local features from sMRI scans without any prior knowledge. The framework is lightweight and suitable for end-to-end training. We evaluate the framework on two public datasets (ADNI-1 and ADNI-2) containing 1,340 subjects. On both the AD classification and mild cognitive impairment conversion prediction tasks, our framework achieves competitive results. Furthermore, we generate heat maps that highlight discriminative areas for visual interpretation. Experiments demonstrate the effectiveness of the proposed framework when medical priors are unavailable or the computing resources are limited. The proposed framework is general for 3D medical image analysis with both efficiency and interpretability.

Indexed as

Deep LearningDisease ProgressionAgedAlzheimer DiseaseCerebral CortexCognitive DysfunctionHumansMagnetic Resonance ImagingNeuroimagingPrognosisAlzheimer's diseaseconvolutional neural networkearly diagnosisstructural MRIvisual attention

Identifiers

PMID34676625
PMCPMC8720194

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.