Evidence map›Paper›PMID 34676508›Full record

ArticleClinical journal of gastroenterology2022

Thymoma-associated autoimmune enteropathy with colonic stricture: a diagnostic and histological challenge.

Bo Pieplenbosch, Jacobus H de Leijer, Willemijn A van Dop, Iris D Nagtegaal, Elisabeth M Witteman

Abstract read
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Article in Clinical journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Bo PieplenboschDivision of Gastroenterology and Hepatology, Canisius Wilhelmina Ziekenhuis Nijmegen, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands.
Jacobus H de LeijerDivision of Gastroenterology and Hepatology, Canisius Wilhelmina Ziekenhuis Nijmegen, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands.
Willemijn A van DopDivision of Gastroenterology and Hepatology, Radboud UMC, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
Iris D NagtegaalDivision of Pathology, Radboud UMC, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
Elisabeth M WittemanDivision of Gastroenterology and Hepatology, Canisius Wilhelmina Ziekenhuis Nijmegen, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands. e.witteman@cwz.nl.ORCID http://orcid.org/0000-0002-3657-3148
Canisius-Wilhelmina Ziekenhuis · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thymoma-associated autoimmune enteropathy is a rare paraneoplastic syndrome that is characterized by severe chronic diarrhea, malabsorption, and specific histological findings. Because of its rarity, it is difficult to diagnose. We describe an adult patient with protracted diarrhea and weight loss that developed recurrent sepsis and progressive colonic stenosis due to thymoma-associated autoimmune enteropathy. Ultimately, the diagnosis thymoma-associated autoimmune enteropathy was established by characteristic intestinal histology, anti-enterocytes antibodies, and thorax imaging. Radical thymectomy was performed without improvement. Therapy with azathioprine and infliximab induced clinical remission with complete recovery of the colonic stenosis.

Indexed as

Polyendocrinopathies, AutoimmuneThymomaThymus NeoplasmsAdultConstriction, PathologicHumansAutoimmune enteropathyDiarrheaGoblet cellsStenosisThymoma

Identifiers

PMID34676508
OpenAlexW3205938413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.