Evidence map›Paper›PMID 34676454›Full record

ArticleMikrochimica acta2021

In situ growth of electroactive polymers via ATRP to construct a biosensing interface for tumor marker.

Fei Wang, Yang Xu, Hongliang Han, Zhanfang Ma

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fei Wang *Department of Chemistry, Capital Normal University, Beijing, 100048, China.
Yang Xu *Department of Chemistry, Capital Normal University, Beijing, 100048, China.
Hongliang HanDepartment of Chemistry, Capital Normal University, Beijing, 100048, China. hanhongliang@cnu.edu.cn.
Zhanfang MaDepartment of Chemistry, Capital Normal University, Beijing, 100048, China. mazhanfang@cnu.edu.cn.

Funding

capacity building for sci-tech innovation-fundamental scientific research funds 20530290055capacity building for sci-tech innovation-fundamental scientific research funds 20530290087joint project of beijing municipal education commission and beijing natural science foundation KZ202110028042national natural science foundation of china 21673143national natural science foundation of china 22172104
6 · The paper itself

Abstract

A novel biosensing interface for tumor markers was designed based on the atom transfer radical polymerization (ATRP) of poly(isopropenylphenol) (PPPL) in situ initiated by the fixing of p-chloromethyl benzoic acid on the surface of amino-modified electrodes. It was found that the electrochemical activity of PPPL itself can provide sufficient signals for these biosensors, which can avoid signal leakage and streamline the interface modification process. Cu(II) ions absorbed on the carbon spheres and then were released via acid stimulation to act as a catalyst to participate in the interface polymerization with ATRP. As the concentration of targets increased, more Cu(II) ions were released, and the electrochemical signal of polymers was enhanced. Therefore, the sensitive detection of carbohydrate antigen 19-9 (CA19-9) as a model target was achieved, with an ultralow limit of detection of 39 µU mL

Indexed as

Biomarkers, TumorBiosensing TechniquesElectrochemical TechniquesHumansPolymersBiomarkers, TumorPolymersElectroactive polymersElectrochemical biosensorIn situ ATRP reactionInterface modificationPoly(isopropenylphenol)Square wave voltammetryTumor marker

Identifiers

PMID34676454

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.