Evidence map›Paper›PMID 34676447›Full record

ArticleJournal of neurology2022

Involvement of cortico-efferent tracts in flail arm syndrome: a tract-of-interest-based DTI study.

Angela Rosenbohm, Kelly Del Tredici, Heiko Braak, Hans-Jürgen Huppertz, Albert C Ludolph, Hans-Peter Müller, Jan Kassubek

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Potential Roles of Neuroimaging in Motor Neuron Disease.Current neurology and neuroscience reports · 2026
    Review
  2. The Flail Limb Syndrome.Muscle & nerve · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Angela RosenbohmDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Kelly Del TrediciDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Heiko BraakDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Hans-Jürgen HuppertzSwiss Epilepsy Clinic, Klinik Lengg, Zurich, Switzerland.
Albert C LudolphDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Hans-Peter Müller *Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Jan Kassubek *Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany. jan.kassubek@uni-ulm.de.ORCID http://orcid.org/0000-0002-7106-9270
Universität Ulm · DESwiss Epilepsy Center · CH

Funding

bmbf 01GM1103Adeutsche forschungsgemeinschaft LU 336/15-1
6 · The paper itself

Abstract

backgroundFlail arm syndrome is a restricted phenotype of motor neuron disease that is characterized by progressive, predominantly proximal weakness and atrophy of the upper limbs.

objectiveThe study was designed to investigate specific white matter alterations in diffusion tensor imaging (DTI) data from flail arm syndrome patients using a hypothesis-guided tract-of-interest-based approach to identify in vivo microstructural changes according to a neuropathologically defined amyotrophic lateral sclerosis (ALS)-related pathology of the cortico-efferent tracts.

methodsDTI-based white matter mapping was performed both by an unbiased voxel-wise statistical comparison and by a hypothesis-guided tract-wise analysis of fractional anisotropy (FA) maps according to the neuropathological ALS-propagation pattern for 43 flail arm syndrome patients vs 43 'classical' ALS patients vs 40 matched controls.

resultsThe analysis of white matter integrity demonstrated regional FA reductions for the flail arm syndrome group predominantly along the CST. In the tract-specific analysis according to the proposed sequential cerebral pathology pattern of ALS, the flail arm syndrome patients showed significant alterations of the specific tract systems that were identical to 'classical' ALS if compared to controls.

conclusionsThe DTI study including the tract-of-interest-based analysis showed a microstructural involvement pattern in the brains of flail arm syndrome patients, supporting the hypothesis that flail arm syndrome is a phenotypical variant of ALS.

Indexed as

Amyotrophic Lateral SclerosisVascular DiseasesAnisotropyArmBrain MappingDiffusion Tensor ImagingDisease ProgressionHumansImage Processing, Computer-AssistedPyramidal TractsAmyotrophic lateral sclerosisDiffusion tensor imagingFlail arm syndromeMagnetic resonance imagingMotor neuron disease

Identifiers

PMID34676447
PMCPMC9021061
OpenAlexW3206040576

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.