Evidence map›Paper›PMID 34676442›Full record

ArticleAmino acids2021

Insulin stimulates β-alanine uptake in skeletal muscle cells in vitro.

Lívia Santos, L S Gonçalves, Shirin Bagheri-Hanei, Gabriella Berwig Möller, Craig Sale, Ruth M James, Guilherme Giannini Artioli

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Carnosine-Related Metabolism in Rat Cardiomyocytes and Human Heart Tissue.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Physiological Roles of Carnosine in Myocardial Function and Health.Advances in nutrition (Bethesda, Md.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Lívia SantosMusculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement Research Centre, Nottingham Trent University, Nottingham, UK.
L S GonçalvesApplied Physiology and Nutrition Research GroupRheumatology DivisionFaculdade de Medicina FMUSPEscola de Educação Física E Esporte, Universidade de São Paulo, São Paulo, SP, Brazil.
Shirin Bagheri-HaneiCollege of Engineering and Physical Science, Aston University, Birmingham, B4 7ET, UK.
Gabriella Berwig MöllerApplied Physiology and Nutrition Research GroupRheumatology DivisionFaculdade de Medicina FMUSPEscola de Educação Física E Esporte, Universidade de São Paulo, São Paulo, SP, Brazil.
Craig SaleMusculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement Research Centre, Nottingham Trent University, Nottingham, UK.
Ruth M JamesMusculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement Research Centre, Nottingham Trent University, Nottingham, UK.
Guilherme Giannini ArtioliDepartment of Life Sciences, Manchester Metropolitan University, John Dalton Building, Manchester, M1 5GD, UK. G.Giannini.Artioli@mmu.ac.uk.ORCID http://orcid.org/0000-0001-8463-2213
Nottingham Trent University · GBUniversidade de São Paulo · BRAston University · GBManchester Metropolitan University · GB

Funding

FAPESP 2014/11948-8FAPESP 2019/25032-9
6 · The paper itself

Abstract

We evaluated whether insulin could stimulate β-alanine uptake by skeletal muscle cells in vitro. Mouse myoblasts (C2C12) (n = 3 wells per condition) were cultured with β-alanine (350 or 700 µmol·L

Indexed as

Animalsbeta-AlanineBiological TransportCell LineInsulinMiceMuscle Fibers, SkeletalMyoblastsbeta-AlanineInsulinCarnosineInsulinTaurine transporterβ-alanine

Identifiers

PMID34676442
PMCPMC8592947
OpenAlexW3205991233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.