Evidence map›Paper›PMID 34676378›Full record

ArticleAdvances in geriatric medicine and research2021

Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions.

Lori A Birder, Edwin K Jackson

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in geriatric medicine and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lori A BirderRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh PA 15261, USA.
Edwin K JacksonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh PA 15261, USA.
University of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Bladder Mucosal Dysfunction During AgingR01AG056944 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L, BIRDER, LORI A · 2018 to 2022
$3.2M
Role of Purine Dysregulation in the Underactive BladderR56AG063753 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRDER, LORI A, JACKSON, EDWIN KERRY · 2019 to 2019
$691k
NIA NIH HHS R01 AG056944NIA NIH HHS R56 AG063753NIDDK NIH HHS P30 DK079307
6 · The paper itself

Abstract

Lower urinary tract (LUT) dysfunction is common in the older adult. Aging is associated with a number of both storage and voiding problems which are classified into syndromes with overlapping symptoms. Despite the prevalence and consequences of these syndromes, LUT disorders continue to be undertreated as few therapeutic options exist. Here, we propose that dysregulated metabolism of purine nucleotides results in an accumulation of uro-damaging hypoxanthine (a source of reactive oxygen species or ROS), which provides a mechanism for defects in sensory signaling and contractility, culminating in abnormal urodynamic behavior.

Indexed as

8-aminoguanineaginglower urinary tractpurine nucleoside phosphorylase

Identifiers

PMID34676378
PMCPMC8527459
OpenAlexW3201831722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.