Evidence map›Paper›PMID 34676358›Full record

ArticleNature machine intelligence2021

A Versatile Deep Learning Architecture for Classification and Label-Free Prediction of Hyperspectral Images.

Bryce Manifold, Shuaiqian Men, Ruoqian Hu, Dan Fu

Abstract read
In one paragraph

Article in Nature machine intelligence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. PLANCK: super-multiplex optical imaging without labeling.bioRxiv : the preprint server for biology · 2026
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  18. Hyperspectral Information Extraction With Full Resolution From Arbitrary Photographs.IEEE transactions on image processing : a publication of the IEEE Signal Processing Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bryce ManifoldDepartment of Chemistry, University of Washington, Seattle, WA, USA.
Shuaiqian MenDepartment of Chemistry, University of Washington, Seattle, WA, USA.
Ruoqian HuDepartment of Chemistry, University of Washington, Seattle, WA, USA.
Dan FuDepartment of Chemistry, University of Washington, Seattle, WA, USA.

Funding

Non-perturbative imaging of intracellular drug exposure and drug response of kinase inhibitors - Admin SuppR35GM133435 · NIGMS · UNIVERSITY OF WASHINGTON · PI Dan Fu · 2019 to 2026
$2.8M
NIGMS NIH HHS R35 GM133435
6 · The paper itself

Abstract

Hyperspectral imaging is a technique that provides rich chemical or compositional information not regularly available to traditional imaging modalities such as intensity imaging or color imaging based on the reflection, transmission, or emission of light. Analysis of hyperspectral imaging often relies on machine learning methods to extract information. Here, we present a new flexible architecture, the U-within-U-Net, that can perform classification, segmentation, and prediction of orthogonal imaging modalities on a variety of hyperspectral imaging techniques. Specifically, we demonstrate feature segmentation and classification on the Indian Pines hyperspectral dataset and simultaneous location prediction of multiple drugs in mass spectrometry imaging of rat liver tissue. We further demonstrate label-free fluorescence image prediction from hyperspectral stimulated Raman scattering microscopy images. The applicability of the U-within-U-Net architecture on diverse datasets with widely varying input and output dimensions and data sources suggest that it has great potential in advancing the use of hyperspectral imaging across many different application areas ranging from remote sensing, to medical imaging, to microscopy.

Identifiers

PMID34676358
PMCPMC8528004

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.