Evidence map›Paper›PMID 34676065›Full record

ArticleTherapeutic advances in endocrinology and metabolism2021

Circulating microRNA-194 levels in Chinese patients with diabetic kidney disease: a case-control study.

Ning Ma, Ning Xu, Dong Yin, Ping Zheng, Weiwei Liu, Guofeng Wang, Yuan Hui, Jiping Zhang, Guanjun Han, Chuanhui Yang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Ning MaDepartment of Endocrinology and Metabolism, The First People's Hospital of Lianyungang, Lianyungang, China.ORCID https://orcid.org/0000-0001-7570-3120
Ning XuDepartment of Endocrinology and Metabolism, The First People's Hospital of Lianyungang, Lianyungang, China.
Dong YinDepartment of Endocrinology and Metabolism, The First People's Hospital of Lianyungang, Lianyungang, China.
Ping ZhengDepartment of Endocrinology and Metabolism, The First People's Hospital of Lianyungang, Lianyungang, China.
Weiwei LiuDepartment of Endocrinology and Metabolism, The First People's Hospital of Lianyungang, Lianyungang, China.
Guofeng WangDepartment of Endocrinology and Metabolism, The First People's Hospital of Lianyungang, Lianyungang, China.
Yuan HuiDepartment of Endocrinology and Metabolism, The First People's Hospital of Lianyungang, Lianyungang, China.
Jiping ZhangDepartment of Endocrinology and Metabolism, The First People's Hospital of Lianyungang, Lianyungang, China.
Guanjun HanDepartment of Endocrinology and Metabolism, The First People's Hospital of Lianyungang, Lianyungang, China.
Chuanhui YangDepartment of Endocrinology and Metabolism, The First People's Hospital of Lianyungang, Lianyungang, China.
Yiting ChenDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xingbo ChengDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou 215006, Jiangsu, China.
Ming ChengSchool of Rail Transportation, Soochow University, 1 Shizi Road, Suzhou 215006, Jiangsu, China.
The First People’s Hospital of Lianyungang · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMicroRNAs (miRNAs) regulate gene expression and are involved in diabetic kidney disease (DKD) pathogenesis. We investigated circulating miRNA-194 levels as a biomarker of DKD prevalence and incidence, and the relationship between miRNA-194 and CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP).

methodsWe recruited 136 type-2 diabetes mellitus (T2DM) patients at the First People's Hospital of Lianyungang and 127 healthy individuals. Circulating miRNA-194 and CHOP levels were measured using quantitative reverse transcription qRT-PCR and enzyme-linked immunosorbent assay (ELISA), respectively. Anthropometric and biochemistry measurements were also made.

resultsT2DM patients showed higher circulating miRNA-194 (

conclusionCirculating miRNA-194 levels could be a novel biomarker for DKD.

Indexed as

CCAAT/enhancer binding protein homology protein (CHOP)diabetic kidney disease (DKD)endoplasmic reticulum stressmicroRNA-194type-2 diabetes mellitus

Identifiers

PMID34676065
PMCPMC8524709
OpenAlexW3206623662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.