Evidence map›Paper›PMID 34676064›Full record

ArticleParkinson's disease2021

Off Time Independently Affects Quality of Life in Advanced Parkinson's Disease (APD) Patients but Not in Non-APD Patients: Results from the Self-Reported Japanese Quality-of-Life Survey of Parkinson's Disease (JAQPAD) Study.

Yuka Hayashi, Ryoko Nakagawa, Miwako Ishido, Yoko Yoshinaga, Jun Watanabe, Kanako Kurihara, Koichi Nagaki, Hiromu Ogura, Takayasu Mishima, Shinsuke Fujioka and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yuka HayashiDepartment of Neurology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan.ORCID https://orcid.org/0000-0001-8970-1978
Ryoko NakagawaMedical, AbbVie GK, 3-1-21 Shibaura, Minato-ku, Tokyo 108-0023, Japan.ORCID https://orcid.org/0000-0002-7037-6762
Miwako IshidoMedical, AbbVie GK, 3-1-21 Shibaura, Minato-ku, Tokyo 108-0023, Japan.ORCID https://orcid.org/0000-0002-8364-6856
Yoko YoshinagaMedical, AbbVie GK, 3-1-21 Shibaura, Minato-ku, Tokyo 108-0023, Japan.ORCID https://orcid.org/0000-0003-4664-0671
Jun WatanabeMedical, AbbVie GK, 3-1-21 Shibaura, Minato-ku, Tokyo 108-0023, Japan.ORCID https://orcid.org/0000-0002-4575-9358
Kanako KuriharaDepartment of Neurology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan.ORCID https://orcid.org/0000-0003-1020-5053
Koichi NagakiDepartment of Neurology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan.ORCID https://orcid.org/0000-0003-0519-5639
Hiromu OguraDepartment of Neurology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan.ORCID https://orcid.org/0000-0003-3962-8682
Takayasu MishimaDepartment of Neurology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan.ORCID https://orcid.org/0000-0002-4649-0434
Shinsuke FujiokaDepartment of Neurology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan.ORCID https://orcid.org/0000-0001-9901-9008
Yoshio TsuboiDepartment of Neurology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan.ORCID https://orcid.org/0000-0002-6758-0981
Fukuoka University · JPABB (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionParkinson's disease (PD) is characterized by a triad of motor symptoms and several nonmotor symptoms (NMS). Identifying the most appropriate treatment is essential for improving patient quality of life (QoL). However, it is still not known which PD symptoms more commonly affect patients with advanced PD (APD) versus non-APD. This study examined the factors that most affected the QoL of patients with APD (defined using the 5-2-1 criteria: ≥5 oral levodopa doses a day, off time ≥2 hours a day, or troublesome dyskinesia ≥1 hour a day) versus non-APD in a large Japanese population using the Japanese Quality-of-Life Survey of Parkinson's Disease (JAQPAD) study.

methodsParticipants in this self-reported survey-based study included all members of the Japan Parkinson's Disease Association. Questionnaires assessing NMS and QoL (e.g., the 8-item PD Questionnaire [PDQ-8]) were included. Univariate and multivariate regression analyses were conducted to identify clinical factors impacting QoL using the PDQ-8 Summary Index (PDQ-8 SI).

resultsOf the 3022 eligible patients, 864 were classified as having non-APD and 1599 as having APD. QoL as assessed by the PDQ-8 SI was notably worse in patients with APD versus non-APD (39.2 vs. 26.9,

conclusionsThis study identified the factors more commonly associated with worse QoL in patients with APD versus non-APD. Our findings offer new insights for providing optimal treatment and improving treatment satisfaction in patients with PD.

Identifiers

PMID34676064
PMCPMC8526216
OpenAlexW3206132734

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.